Ceftaroline fosamil: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Is Generation::5th generation]] [[Is DrugClass::Cephalosporin]] | ||
*Dosage Forms: | *Dosage Forms: injectable, powder for reconstitution | ||
*Common Trade Names: | *Dosage Strengths: 400mg/vial, 600mg/vial | ||
*Routes of Administration: IV | |||
*Common Trade Names: Teflaro | |||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Pneumonia (Main)|Community Acquired Pneumonia]]=== | |||
*600mg IV q12h x5-7 days | |||
===[[Cellulitis]]=== | |||
*600mg IV q12h x5-14 days | |||
===Renal Dosing=== | |||
*CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h | |||
===Hepatic Dosing=== | |||
*No adjustment | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Currently no pediatric dosing for this drug. | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:B | ||
*Lactation: | *Lactation: Safety Unknown | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h | ||
**Pediatric | **Pediatric: Drug not available for pediatrics | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: No Adjustment | ||
**Pediatric | **Pediatric: NA | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug (see also [[Cephalosporin Cross-reactivity]]) | ||
*Caution if hypersensitive to beta-lactams | |||
*Caution if recent antibiotic-associated colitis history | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | |||
*[[Hypersensitivity Reaction]] | |||
*[[Clostridium difficile]] associated diarrhea | |||
*SUPERINFECTION | |||
*Hemolytic [[Anemia]] | |||
===Common=== | ===Common=== | ||
*[[Diarrhea]] | |||
*[[Nausea]] | |||
*[[Rash]] | |||
*[[Constipation]] | |||
*[[Vomiting]] | |||
*ALT, AST elevated | |||
*[[Hypokalemia]] | |||
*Phlebitis | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2.6 Hours | ||
*Metabolism: | *Metabolism: Hydrolysis; CYP450: none; prodrug converted to ceftaroline | ||
*Excretion: | *Excretion: Urine primarily | ||
*Mechanism of Action: | *Mechanism of Action: Bactericidal, inhibits cell wall mucopeptide synthesis | ||
==See Also== | ==See Also== | ||
*[[Antibiotics (Main)]] | |||
== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] [[Category:ID]] | |||
Latest revision as of 16:22, 18 July 2025
General
- Type: 5th generation Cephalosporin
- Dosage Forms: injectable, powder for reconstitution
- Dosage Strengths: 400mg/vial, 600mg/vial
- Routes of Administration: IV
- Common Trade Names: Teflaro
Adult Dosing
Community Acquired Pneumonia
- 600mg IV q12h x5-7 days
Cellulitis
- 600mg IV q12h x5-14 days
Renal Dosing
- CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
Hepatic Dosing
- No adjustment
Pediatric Dosing
- Currently no pediatric dosing for this drug.
Special Populations
- Pregnancy Rating:B
- Lactation: Safety Unknown
- Renal Dosing
- Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
- Pediatric: Drug not available for pediatrics
- Hepatic Dosing
- Adult: No Adjustment
- Pediatric: NA
Contraindications
- Allergy to class/drug (see also Cephalosporin Cross-reactivity)
- Caution if hypersensitive to beta-lactams
- Caution if recent antibiotic-associated colitis history
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity Reaction
- Clostridium difficile associated diarrhea
- SUPERINFECTION
- Hemolytic Anemia
Common
- Diarrhea
- Nausea
- Rash
- Constipation
- Vomiting
- ALT, AST elevated
- Hypokalemia
- Phlebitis
Pharmacology
- Half-life: 2.6 Hours
- Metabolism: Hydrolysis; CYP450: none; prodrug converted to ceftaroline
- Excretion: Urine primarily
- Mechanism of Action: Bactericidal, inhibits cell wall mucopeptide synthesis