Template:GC Conjunctivitis Treatment: Difference between revisions
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(Update Ceftriaxone dose for gonococcal conjunctivitis per CDC 2021 guidelines: 250mg → 1g IM) |
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====Chlamydial==== | ====[[chlamydia conjunctivitis|Chlamydial]]==== | ||
* | *{{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Doxycycline|dose=100mg PO BID for 7 days|context=Chlamydial Conjunctivitis}} OR | ||
* | *{{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Azithromycin|dose=1g (20mg/kg) PO one time dose|context=Chlamydial Conjunctivitis}} | ||
*'''Newborn Treatment:''' {{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Azithromycin|dose=20mg/kg PO once daily x 3 days|context=Chlamydial Conjunctivitis, Newborn|population=Pediatric}} or erythromycin PO 50 mg/kg/day in 4 divided doses for 14 days <ref>Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N. Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329; PMCID: PMC6097578.</ref> | |||
**Disease manifests 5 days post-birth to 2 weeks (late onset) | |||
====Gonococcal==== | ====[[gonorrheal conjunctivitis|Gonococcal]]==== | ||
* | *Due to increasing resistance, CDC recommends dual therapy with Ceftriaxone and Azithromycin (even if patient is negative for Chlamydia). | ||
* | *{{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Ceftriaxone|dose=1g IM single dose|context=Gonococcal Conjunctivitis}} PLUS | ||
*{{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Azithromycin|dose=1g PO one dose|context=Gonococcal Conjunctivitis}} | |||
*'''Newborn Treatment:''' | |||
**Prophylaxis: [[Erythromycin]] ophthalmic 0.5% x1 | |||
**Disease manifests 1st 5 days post delivery (early onset) | |||
**Treatment {{AntibioticDose|disease=Gonorrheal conjunctivitis|drug=Ceftriaxone|dose=25-50mg IV or IM, max 125mg|context=Gonococcal Conjunctivitis, Newborn|population=Pediatric}} or cefotaxime single dose of 100 mg/kg (preferred if the patient has hyperbilirubinemia) | |||
**Also requires evaluation for disseminated disease (meningitis, arthritis, etc.) | |||
Latest revision as of 11:35, 20 March 2026
Chlamydial
- Doxycycline 100mg PO BID for 7 days OR
- Azithromycin 1g (20mg/kg) PO one time dose
- Newborn Treatment: Azithromycin 20mg/kg PO once daily x 3 days or erythromycin PO 50 mg/kg/day in 4 divided doses for 14 days [1]
- Disease manifests 5 days post-birth to 2 weeks (late onset)
Gonococcal
- Due to increasing resistance, CDC recommends dual therapy with Ceftriaxone and Azithromycin (even if patient is negative for Chlamydia).
- Ceftriaxone 1g IM single dose PLUS
- Azithromycin 1g PO one dose
- Newborn Treatment:
- Prophylaxis: Erythromycin ophthalmic 0.5% x1
- Disease manifests 1st 5 days post delivery (early onset)
- Treatment Ceftriaxone 25-50mg IV or IM, max 125mg or cefotaxime single dose of 100 mg/kg (preferred if the patient has hyperbilirubinemia)
- Also requires evaluation for disseminated disease (meningitis, arthritis, etc.)
- ↑ Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N. Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329; PMCID: PMC6097578.