Jimson weed: Difference between revisions
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==Background== | |||
[[File:Jimson_weed.png|thumb|Datura stramonium aka Jimson Weed]] | |||
*Contains up to 28 different anticholinergic alkaloids<ref>Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.</ref> | |||
**[[Atropine]], [[hyoscyamine]], and [[scopolamine]] | |||
*All parts of the plant are toxic but the highest concentration is in the seeds | |||
**50-100 seeds in each pod | |||
**100 seeds is the equivalent of about 6mg atropine | |||
*Estimated lethal doses of atropine in adults ≥10mg<ref>Shervette RE, et al. Jimson "loco" weed abuse in adolescents. Pediatrics. 1979; 63:520-523.</ref> | |||
[[ | ===Administration=== | ||
*Inhalation (smoking dried leaves or other plant parts) | |||
*Ingestion (eating plant parts or foods containing extracts) | |||
==Clinical Features== | |||
*History of plant ingestion/smoking | |||
*[[Anticholinergic toxicity|Anticholinergic toxidrome]] | |||
*Symptoms can last for days if seeds were ingested | |||
==Differential Diagnosis== | |||
*Sympathomimetic toxicity | |||
**Red, dry skin and absent bowel sounds favors anticholinergic toxicity | |||
*Encephalitis | |||
*Head trauma | |||
*ETOH/sedative withdrawal | |||
*[[Neuroleptic Malignant Syndrome (NMS)]] | |||
*Acute psychotic disorder | |||
{{Anticholinergic types}} | |||
==Evaluation== | |||
Clinical diagnosis with history and physical exam | |||
{{Clinical Features Anticholinergic Toxicity}} | |||
==Management== | |||
*Supportive care and patient reassurance | |||
*Sedation as needed with benzos | |||
*In severe cases, [[physostigmine]] 0.5–2.0 mg IV at a rate of no more than 1mg/min (adult dosing) | |||
**A second dose may be administered if necessary | |||
**Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min | |||
**Note that [[pyridostigmine]] does not cross the blood brain barrier, and is a poor agent for agitation, CNS features | |||
==Medication Dosing== | |||
{{MedicationDose | |||
| drug = Physostigmine | |||
| dose = 0.5-2mg IV at rate no more than 1mg/min | |||
| route = IV | |||
| context = Severe anticholinergic toxicity | |||
| indication = Jimson weed | |||
| population = Adult | |||
}} | |||
{{MedicationDose | |||
| drug = Physostigmine | |||
| dose = 0.02mg/kg IV at rate no more than 0.5mg/min | |||
| route = IV | |||
| context = Severe anticholinergic toxicity | |||
| indication = Jimson weed | |||
| population = Pediatric | |||
}} | |||
==See Also== | |||
*[[Anticholinergic toxicity]] | |||
*[[Toxicology (Main)]] | |||
==References== | |||
<references/> | |||
[[Category:Toxicology]] | |||
Latest revision as of 21:17, 20 March 2026
Background
- Contains up to 28 different anticholinergic alkaloids[1]
- Atropine, hyoscyamine, and scopolamine
- All parts of the plant are toxic but the highest concentration is in the seeds
- 50-100 seeds in each pod
- 100 seeds is the equivalent of about 6mg atropine
- Estimated lethal doses of atropine in adults ≥10mg[2]
Administration
- Inhalation (smoking dried leaves or other plant parts)
- Ingestion (eating plant parts or foods containing extracts)
Clinical Features
- History of plant ingestion/smoking
- Anticholinergic toxidrome
- Symptoms can last for days if seeds were ingested
Differential Diagnosis
- Sympathomimetic toxicity
- Red, dry skin and absent bowel sounds favors anticholinergic toxicity
- Encephalitis
- Head trauma
- ETOH/sedative withdrawal
- Neuroleptic Malignant Syndrome (NMS)
- Acute psychotic disorder
Anticholinergic toxicity Causes
- Medications[3]
- Atropine
- Antihistamines
- Antidepressants
- Antipsychotics
- Muscle relaxants
- Anti-Parkinsonians
- Plants
- Jimson weed (Devil's trumpet)
- Amanita mushroom
Evaluation
Clinical diagnosis with history and physical exam
- Red as a beet: cutaneous vasodilation
- Blind as a bat: nonreactive mydriasis (often delayed 12-24hr)
- Mad as a hatter: delirium; attention deficit; hallucinations; dysarthria; lethargy
- Full as a flask: urinary retention
- Hot as a hare: anhydrotic hyperthermia (may become severe w/ agitation)
- Dry as a bone: anhidrosis (esp axillae, mouth)
- And the heart runs alone: Tachycardia (HR 120-160) and decreased/absent bowel sounds
Management
- Supportive care and patient reassurance
- Sedation as needed with benzos
- In severe cases, physostigmine 0.5–2.0 mg IV at a rate of no more than 1mg/min (adult dosing)
- A second dose may be administered if necessary
- Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min
- Note that pyridostigmine does not cross the blood brain barrier, and is a poor agent for agitation, CNS features
Medication Dosing
Physostigmine 0.5-2mg IV at rate no more than 1mg/min IV Physostigmine 0.02mg/kg IV at rate no more than 0.5mg/min IV
See Also
References
- ↑ Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.
- ↑ Shervette RE, et al. Jimson "loco" weed abuse in adolescents. Pediatrics. 1979; 63:520-523.
- ↑ Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.