Template:Endometritis Antibiotics: Difference between revisions
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====<48hrs Post Partum==== | ====<48hrs Post Partum==== | ||
''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ||
* | *(Preferred first line) {{AntibioticDose|disease=Postpartum endometritis|drug=Clindamycin|dose=900mg IV q8hrs|context=Preferred first line; <48hrs postpartum}} PLUS {{AntibioticDose|disease=Postpartum endometritis|drug=Gentamicin|dose=5mg/kg IV q24hrs or 1.5mg/kg IV q8hrs|context=Combined with Clindamycin; <48hrs postpartum}}<ref>Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613</ref> OR | ||
* | *{{AntibioticDose|disease=Postpartum endometritis|drug=Doxycycline|dose=100mg IV/PO q12hrs|context=<48hrs postpartum; combined with Ampicillin/Sulbactam or Cefoxitin}} PLUS | ||
** | **{{AntibioticDose|disease=Postpartum endometritis|drug=Ampicillin/Sulbactam|dose=3g IV q6hrs|context=<48hrs postpartum; combined with Doxycycline}} | ||
** | **{{AntibioticDose|disease=Postpartum endometritis|drug=Cefoxitin|dose=2g IV q6hrs|context=<48hrs postpartum; combined with Doxycycline}} | ||
====>48hrs Post Partum==== | ====>48hrs Post Partum==== | ||
* | *{{AntibioticDose|disease=Postpartum endometritis|drug=Doxycycline|dose=100mg IV or PO q12hrs|context=>48hrs postpartum; combined with Metronidazole}} + {{AntibioticDose|disease=Postpartum endometritis|drug=Metronidazole|dose=500mg IV or PO q8hrs|context=>48hrs postpartum; combined with Doxycycline}} | ||
**Use Metronidazole with caution in breastfeeding mothers as its active metabolite is present in breast milk at concentrations similar to maternal plasma concentrations | |||
Latest revision as of 02:24, 20 March 2026
<48hrs Post Partum
Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora
- (Preferred first line) Clindamycin 900mg IV q8hrs PLUS Gentamicin 5mg/kg IV q24hrs or 1.5mg/kg IV q8hrs[1] OR
- Doxycycline 100mg IV/PO q12hrs PLUS
- Ampicillin/Sulbactam 3g IV q6hrs
- Cefoxitin 2g IV q6hrs
>48hrs Post Partum
- Doxycycline 100mg IV or PO q12hrs + Metronidazole 500mg IV or PO q8hrs
- Use Metronidazole with caution in breastfeeding mothers as its active metabolite is present in breast milk at concentrations similar to maternal plasma concentrations
- ↑ Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613