Oxycodone: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Opioid]] | ||
*Dosage Forms: PO | *Dosage Forms: PO | ||
*Common Trade Names: Roxicodone, Oxycontin | *Common Trade Names: Roxicodone, Oxycontin | ||
*Commonly combined with [[acetaminophen]] as Percocet | |||
==Adult Dosing== | ==Adult Dosing== | ||
=== | ===Opioid-Naive Patients=== | ||
*Start: 5-15mg PO q4-6h PRN | |||
* | **Use lowest effective dose and shortest effective duration (NOT a first-line treatment) | ||
**Use caution in older patients | |||
===Opioid-Experienced Patients=== | |||
*Individualize based on current opioid intake q4-6h PRN | |||
**Use caution in older patients | |||
**See [[Opioids#Oral_Opioid_Dosing_Chart|Opioid Dosing Chart]] for dose conversion information | |||
**Taper dose by 25-50% q2-4 days to discontinue if long-term use | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Pain | ===General Pain=== | ||
*0.05-0. | *0.05-0.15mg/kg PO q4-6h PRN | ||
*Max: 5mg/dose | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
| Line 29: | Line 39: | ||
*Respiratory Depression | *Respiratory Depression | ||
*Apnea | *Apnea | ||
* | *[[Syncope]] | ||
* | *[[Bradycardia]] | ||
*Seizures | *[[Seizures]] | ||
* | *[[Anaphylaxis]] | ||
===Common=== | ===Common=== | ||
| Line 49: | Line 59: | ||
*Excretion: urine | *Excretion: urine | ||
*Mechanism of Action:binds to various opioid receptors | *Mechanism of Action:binds to various opioid receptors | ||
==See Also== | |||
*[[Opioids]] | |||
*[[Acute pain management]] | |||
*[[Opioid overdose]] | |||
==References== | |||
<references/> | |||
[[Category:Pharmacology]] | |||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Oxycodone]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
Latest revision as of 09:13, 22 March 2026
General
- Type: Opioid
- Dosage Forms: PO
- Common Trade Names: Roxicodone, Oxycontin
- Commonly combined with acetaminophen as Percocet
Adult Dosing
Opioid-Naive Patients
- Start: 5-15mg PO q4-6h PRN
- Use lowest effective dose and shortest effective duration (NOT a first-line treatment)
- Use caution in older patients
Opioid-Experienced Patients
- Individualize based on current opioid intake q4-6h PRN
- Use caution in older patients
- See Opioid Dosing Chart for dose conversion information
- Taper dose by 25-50% q2-4 days to discontinue if long-term use
Pediatric Dosing
General Pain
- 0.05-0.15mg/kg PO q4-6h PRN
- Max: 5mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: possibly unsafe
- Renal Dosing
- Adult: CrCl < 60: decrease starting dose
- Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Respiratory Depression
- Apnea
- Syncope
- Bradycardia
- Seizures
- Anaphylaxis
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- transaminitis
Pharmacology
- Half-life: 3.5-4 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:binds to various opioid receptors
See Also
References
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Acute pain management | 5-10 mg PO q4-6h PRN | Step 2 - Moderate pain (mild opioid) | PO | Adult |