Labetalol: Difference between revisions
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*Infusion dosing | *Infusion dosing | ||
**0.5-2mg/min | **0.5-2mg/min | ||
===[[Intracranial hemorrhage]]=== | |||
*Start with labetalol 20mg over 1-2 minutes | |||
**Then, 20mg q3-5 mins until target blood pressure is achieved | |||
**Then, start an infusion of 1-8mg/min | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: Compatible with breastfeeding | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
*** No renal dosing adjustments necessary. Drug not removed with hemodialysis | |||
**Pediatric | **Pediatric | ||
*** No renal dosing adjustments necessary. Drug not removed with hemodialysis | |||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult | ||
*** May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution. | |||
**Pediatric | **Pediatric | ||
*** May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution. | |||
== Indications == | ==Indications== | ||
* | *hypertension in setting of myocardial ischemia | ||
* | *hypertension in setting of neurologic injury | ||
* | *hypertension in setting of preeclampsia/eclampsia | ||
==Contraindications== | ==Contraindications== | ||
| Line 34: | Line 43: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 5-8hrs | ||
*Metabolism: | *Metabolism: Hepatic via conjugation | ||
*Excretion: | *Excretion: Renal 55-60% | ||
*Mechanism of Action: | *Mechanism of Action: | ||
**Class II - Nonselective | **Class II - Nonselective β-blocker | ||
** | **α<sub>1</sub>-blocker | ||
*Onset of action = 2-5min (IV) | *Onset of action = 2-5min (IV) | ||
*Duration of action = 2-4hr (IV) | *Duration of action = 2-4hr (IV) | ||
==See Also== | ==See Also== | ||
*[[Beta-blockers]] | |||
*[[Beta-blocker toxicity]] | |||
*[[Antiarrhythmics]] | *[[Antiarrhythmics]] | ||
*[[Antihypertensive medications]] | |||
== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. | |||
Latest revision as of 01:19, 7 March 2021
General
- Type: Beta blockers
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Bolus dosing
- 20mg IV followed by 40-80mg q10min up to total of 300mg
- Infusion dosing
- 0.5-2mg/min
Intracranial hemorrhage
- Start with labetalol 20mg over 1-2 minutes
- Then, 20mg q3-5 mins until target blood pressure is achieved
- Then, start an infusion of 1-8mg/min
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Compatible with breastfeeding
- Renal Dosing
- Adult
- No renal dosing adjustments necessary. Drug not removed with hemodialysis
- Pediatric
- No renal dosing adjustments necessary. Drug not removed with hemodialysis
- Adult
- Hepatic Dosing
- Adult
- May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
- Pediatric
- May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
- Adult
Indications
- hypertension in setting of myocardial ischemia
- hypertension in setting of neurologic injury
- hypertension in setting of preeclampsia/eclampsia
Contraindications
- Allergy to class/drug
Adverse Reactions
- Orthostatic hypotension
Pharmacology
- Half-life: 5-8hrs
- Metabolism: Hepatic via conjugation
- Excretion: Renal 55-60%
- Mechanism of Action:
- Class II - Nonselective β-blocker
- α1-blocker
- Onset of action = 2-5min (IV)
- Duration of action = 2-4hr (IV)
See Also
References
Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.