Labetalol: Difference between revisions

Latest revision as of 01:19, 7 March 2021

General

Type: Beta blockers
Dosage Forms:
Common Trade Names:

Adult Dosing

Bolus dosing
- 20mg IV followed by 40-80mg q10min up to total of 300mg
Infusion dosing
- 0.5-2mg/min

Intracranial hemorrhage

Start with labetalol 20mg over 1-2 minutes
- Then, 20mg q3-5 mins until target blood pressure is achieved
- Then, start an infusion of 1-8mg/min

Pediatric Dosing

Special Populations

Pregnancy Rating: C
Lactation: Compatible with breastfeeding
Renal Dosing
- Adult
  - No renal dosing adjustments necessary. Drug not removed with hemodialysis
- Pediatric
  - No renal dosing adjustments necessary. Drug not removed with hemodialysis
Hepatic Dosing
- Adult
  - May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
- Pediatric
  - May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.

Indications

hypertension in setting of myocardial ischemia
hypertension in setting of neurologic injury
hypertension in setting of preeclampsia/eclampsia

Contraindications

Allergy to class/drug

Adverse Reactions

Orthostatic hypotension

Pharmacology

Half-life: 5-8hrs
Metabolism: Hepatic via conjugation
Excretion: Renal 55-60%
Mechanism of Action:
- Class II - Nonselective β-blocker
- α₁-blocker
Onset of action = 2-5min (IV)
Duration of action = 2-4hr (IV)

References

Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.

Authors:

@@ Line 1: / Line 1: @@
-== Adult Dosing ==
+==General==
+*Type: [[Beta blockers]]
+*Dosage Forms:
+*Common Trade Names:
+==Adult Dosing==
 *Bolus dosing
 **20mg IV followed by 40-80mg q10min up to total of 300mg
@@ Line 5: / Line 10: @@
 **0.5-2mg/min
-== Indications ==
+===[[Intracranial hemorrhage]]===
-*HTN in setting of myocardial ischemia
+*Start with labetalol 20mg over 1-2 minutes
-*HTN in setting of neurologic injury
+**Then, 20mg q3-5 mins until target blood pressure is achieved
-*HTN in setting of preeclampsia/eclampsia
+**Then, start an infusion of 1-8mg/min
+==Pediatric Dosing==
+==Special Populations==
+*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
+*Lactation: Compatible with breastfeeding
+*Renal Dosing
+**Adult
+*** No renal dosing adjustments necessary. Drug not removed with hemodialysis
+**Pediatric
+*** No renal dosing adjustments necessary. Drug not removed with hemodialysis
+*Hepatic Dosing
+**Adult
+*** May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
+**Pediatric
+*** May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
+==Indications==
+*hypertension in setting of myocardial ischemia
+*hypertension in setting of neurologic injury
+*hypertension in setting of preeclampsia/eclampsia
-== Mechanism of Action ==
+==Contraindications==
-*Class II - Nonselective beta blocker
+*Allergy to class/drug
-*Alpha1 blocker
-== Adverse Drug Rxns ==
+==Adverse Reactions==
 *Orthostatic hypotension
-== Kinetics ==
+==Pharmacology==
+*Half-life: 5-8hrs
+*Metabolism: Hepatic via conjugation
+*Excretion: Renal 55-60%
+*Mechanism of Action:
+**Class II - Nonselective β-blocker
+**α<sub>1</sub>-blocker
 *Onset of action = 2-5min (IV)
 *Duration of action = 2-4hr (IV)
 ==See Also==
-[[Antiarrhythmics]
+*[[Beta-blockers]]
+*[[Beta-blocker toxicity]]
+*[[Antiarrhythmics]]
+*[[Antihypertensive medications]]
+==References==
+<references/>
+[[Category:Pharmacology]]
+[[Category:Cardiology]]
-[[Cateogry:Drugs]]
+Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.