CHF medications: Difference between revisions
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{| | {| class="wikitable" | ||
|- | |- | ||
|'''Agent''' | |'''Agent''' | ||
|'''RA''' | |'''RA''' | ||
| Line 13: | Line 13: | ||
|- | |- | ||
| | | [[Isordil]] 60 | ||
| - | | - | ||
| - | | - | ||
| (-) | | (-) | ||
| - | | - | ||
| -/+ | | -/+ | ||
|- | |- | ||
| | | [[Hydralazine]] 100 | ||
| ~ | | ~ | ||
| ~ | | ~ | ||
| - | | - | ||
| +/- | | +/- | ||
| ++ | | ++ | ||
|- | |- | ||
| hy (MR/AI) | | hy (MR/AI) | ||
| - | | - | ||
| -- | | -- | ||
| ++ | | ++ | ||
| -/+ | | -/+ | ||
| +/- | | +/- | ||
|- | |- | ||
| ACEI | | [[ACEI]] | ||
| - | | - | ||
| - | | - | ||
| - | | - | ||
| +/- | | +/- | ||
| + | | + | ||
|- | |- | ||
| Minoxidil | | Minoxidil | ||
| ~ | | ~ | ||
| ~ | | ~ | ||
| -- | | -- | ||
| +/- | | +/- | ||
| ++ | | ++ | ||
|} | |} | ||
*Carvedilol: decreases mortality 67% | *[[Carvedilol]]: decreases mortality 67% | ||
*Digoxin: decrease syx/hospitaliz | *[[Digoxin]]: decrease syx/hospitaliz | ||
*Aldactone in Class IV | *Aldactone in Class IV decrease mortality | ||
*Isordil: cor. VD; +BP if ischemia | *[[Isordil]]: cor. VD; +BP if ischemia | ||
*ISDN/HYDRA. decreased mortality in CHF | *ISDN/HYDRA. decreased mortality in CHF | ||
*ACEI GREAT mortality benefit | *ACEI GREAT mortality benefit | ||
== Target Doses == | ==Target Doses== | ||
*Hydralazine: 100 TID start 25 | *[[Hydralazine]]: 100 TID start 25 | ||
*Isordil: 60-80 TID | *Isordil: 60-80 TID | ||
*Captopril: 100 TID start 12.5 | *[[Captopril]]: 100 TID start 12.5 | ||
*Lisinopril/enalapril: 10 | *[[Lisinopril]]/[[enalapril]]: 10 BID class II/III | ||
**20 | **20 BID class IV | ||
*Carvedilol 25 BID; 50 BID if >80kg | *[[Carvedilol]] 25 BID; 50 BID if >80kg | ||
*Digoxin: varies | *[[Digoxin]]: varies | ||
*Spironolactone 25-50 | *[[Spironolactone]] 25-50 QD | ||
*Enalapril 1.25mg IV | *[[Enalapril]] 1.25mg IV | ||
*Nitroglycerin (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 10-200ug/min) | *[[Nitroglycerin]] (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 10-200ug/min) | ||
*Nitroprusside (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 5-400ug/min) | *[[Nitroprusside]] (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 5-400ug/min) | ||
^Consider when need afterload reduction | ^Consider when need afterload reduction | ||
== See Also == | ==See Also== | ||
[[Congestive Heart Failure (CHF)]] | [[Congestive Heart Failure (CHF)]] | ||
[[Category: | [[Category:Cardiology]] | ||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 10:17, 7 July 2017
| Agent | RA | RCW | SVR | BP | CO |
| Isordil 60 | - | - | (-) | - | -/+ |
| Hydralazine 100 | ~ | ~ | - | +/- | ++ |
| hy (MR/AI) | - | -- | ++ | -/+ | +/- |
| ACEI | - | - | - | +/- | + |
| Minoxidil | ~ | ~ | -- | +/- | ++ |
- Carvedilol: decreases mortality 67%
- Digoxin: decrease syx/hospitaliz
- Aldactone in Class IV decrease mortality
- Isordil: cor. VD; +BP if ischemia
- ISDN/HYDRA. decreased mortality in CHF
- ACEI GREAT mortality benefit
Target Doses
- Hydralazine: 100 TID start 25
- Isordil: 60-80 TID
- Captopril: 100 TID start 12.5
- Lisinopril/enalapril: 10 BID class II/III
- 20 BID class IV
- Carvedilol 25 BID; 50 BID if >80kg
- Digoxin: varies
- Spironolactone 25-50 QD
- Enalapril 1.25mg IV
- Nitroglycerin (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 10-200ug/min)
- Nitroprusside (Initial dose 5-10ug/min, increased every 3-5 minute to dose range 5-400ug/min)
^Consider when need afterload reduction