Hydralazine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
* | *hypertension: 10 - 50mg PO QID | ||
* Hypertensive crisis: 10- | *Hypertensive crisis: 10-20mg IM/IV q2-4h | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Hypertensive Crisis: | *Hypertensive Crisis: | ||
# 1 mo - 12 years: 0.1 - 0. | #1 mo - 12 years: 0.1 - 0.5mg/kg IM/IV q4-6h, max dose of 20mg | ||
# > 12 years old: 10 - | #> 12 years old: 10 - 20mg IV q2-4h | ||
==Special Populations== | ==Special Populations== | ||
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* mitral valvular rheumatic heart disease | *mitral valvular rheumatic heart disease | ||
* Caution if renal impairment | *Caution if renal impairment | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
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*MI | *MI | ||
*neutropenia | *neutropenia | ||
*lupus erythematosus | *lupus erythematosus (SLE) | ||
*peripheral neuritis | *peripheral neuritis | ||
| Line 49: | Line 49: | ||
==See Also== | ==See Also== | ||
==References== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Latest revision as of 06:11, 20 August 2022
General
- Type: Vasodilator
- Dosage Forms: 10, 25, 50, 100; PO, IM, IV
- Common Trade Names: Apresoline
Adult Dosing
- hypertension: 10 - 50mg PO QID
- Hypertensive crisis: 10-20mg IM/IV q2-4h
Pediatric Dosing
- Hypertensive Crisis:
- 1 mo - 12 years: 0.1 - 0.5mg/kg IM/IV q4-6h, max dose of 20mg
- > 12 years old: 10 - 20mg IV q2-4h
Special Populations
- Pregnancy Rating: C
- Lactation: Probably Safe
- Renal Dosing
- Adult: CrCl 10-50: give q8h, CrCl <10, give q8-16h
- Pediatric: CrCl 10-50: give q8h, CrCl <10, give q8-16h
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- mitral valvular rheumatic heart disease
- Caution if renal impairment
Adverse Reactions
Serious
- MI
- neutropenia
- lupus erythematosus (SLE)
- peripheral neuritis
Common
- headache
- tachycardia
- angina
- nausea/vomiting
- rash
Pharmacology
- Half-life: 3-7 hours
- Metabolism: liver
- Excretion: urine, feces
- Mechanism of Action: directly dilates peripheral vessels