Tinidazole: Difference between revisions
(Text replacement - "N/V" to "nausea and vomiting") |
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==General== | ==General== | ||
*Type: | *Type: [[Antiparasitic]] | ||
*Dosage Forms: 250, 500 | *Dosage Forms: 250, 500 | ||
*Routes of Administration: PO | *Routes of Administration: PO | ||
| Line 8: | Line 8: | ||
*Give with food | *Give with food | ||
===Intestinal Amebiasis=== | ===Intestinal Amebiasis=== | ||
* | *2000mg PO daily x 3 days | ||
===Amebic liver abscess=== | ===Amebic liver abscess=== | ||
* | *2000mg PO daily x 3-5 days | ||
===Giardiasis=== | ===Giardiasis=== | ||
* | *2000mg PO x 1 | ||
===Trichamoniasis=== | ===Trichamoniasis=== | ||
* | *2000mg PO x 1 | ||
**Treat partner to avoid re-exposure | **Treat partner to avoid re-exposure | ||
===Bacterial vaginosis=== | ===Bacterial vaginosis=== | ||
* | *2000mg PO daily x 2 days '''OR''' 1000mg PO daily x 5 days | ||
*Non-pregnant women only | *Non-pregnant women only | ||
===Urethritis=== | ===Urethritis=== | ||
* | *2000mg PO x 1 | ||
*Give with azithromycin if not treated with azithromycin previously | *Give with azithromycin if not treated with azithromycin previously | ||
| Line 32: | Line 32: | ||
*Give with food | *Give with food | ||
===Intestinal Amebiasis=== | ===Intestinal Amebiasis=== | ||
* | *50mg/kg PO daily x 3 days | ||
*Max | *Max 2000mg/dose | ||
===Amebic liver abscess=== | ===Amebic liver abscess=== | ||
* | *50mg/kg PO daily x 3-5 days | ||
*Max | *Max 2000mg/dose | ||
===Giardiasis=== | ===Giardiasis=== | ||
* | *50mg/kg PO x 1 | ||
*Max | *Max 2000mg/dose | ||
==Special Populations== | ==Special Populations== | ||
| Line 101: | Line 101: | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 23:02, 23 September 2019
General
- Type: Antiparasitic
- Dosage Forms: 250, 500
- Routes of Administration: PO
- Common Trade Names: Tindamax
Adult Dosing
- Give with food
Intestinal Amebiasis
- 2000mg PO daily x 3 days
Amebic liver abscess
- 2000mg PO daily x 3-5 days
Giardiasis
- 2000mg PO x 1
Trichamoniasis
- 2000mg PO x 1
- Treat partner to avoid re-exposure
Bacterial vaginosis
- 2000mg PO daily x 2 days OR 1000mg PO daily x 5 days
- Non-pregnant women only
Urethritis
- 2000mg PO x 1
- Give with azithromycin if not treated with azithromycin previously
Pediatric Dosing
- Approved for age >3 years
- Give with food
Intestinal Amebiasis
- 50mg/kg PO daily x 3 days
- Max 2000mg/dose
Amebic liver abscess
- 50mg/kg PO daily x 3-5 days
- Max 2000mg/dose
Giardiasis
- 50mg/kg PO x 1
- Max 2000mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unsafe
- Renal Dosing
- Adult: Adjust dose amount; 50% usual dose as supplement if on HD
- Pediatric: Adjust dose amount; 50% usual dose as supplement if on HD
- Hepatic Dosing
- Adult: No defined dose adjustment but can cause hepatic impairment. Use with caution.
- Pediatric: No defined dose adjustment but can cause hepatic impairment. Use with caution.
Contraindications
- Allergy to class/drug
- Pregnancy, 1st trimester
- Breastfeeding up to 72 hours after treatment
- Alcohol use up to 72 hours after treatment
- Hepatic impairment
- Blood dyscrasia
- CNS disorder
Adverse Reactions
Serious
- Seizure
- Peripheral neuropathy
- Thrombocytopenia
- Hypersensitivity reaction
- Angioedema
- Stevens-Johnson syndrome
- Erythema multiforme
- Bronchospasm
Common
- nausea and vomiting
- Anorexia
- Metallic taste
- Fatigue/weakness
- Candidiasis
- Flatulence
- UTI
- Pelvic pain
- Vulvovaginal discomfort
- Vaginal odor
- Menorrhagia
- URI
Pharmacology
- Half-life: 12-14 hours
- Metabolism: Liver; CYP450
- Excretion: Urine 20-25%, feces 12%
- Mechanism of Action: Bactericidal; inhibits DNA synthesis
Comments
- Black box warning: Carcinogenic risk
See Also
References
- Epocrates