Clotrimazole: Difference between revisions

Latest revision as of 12:11, 20 March 2026

Administration

Type: Antifungal, azole
Dosage Forms
- Topical:1% cream
- Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
- Oropharyngeal: 10mg troche
Routes of Administration: topical, oropharyngeal, vaginal
Common Trade Names
- Topical: Anti-Fungal Liquid, Desenex AF Prescription Strength, FungiCURE Pump Spray, Lotrimin AF Cream, Lotrimin AF For Her, Lotrimin AF Jock Itch, Lotrimin AF Solution, Lotrimin Jock Itch Powder, MPM Anti-Fungal, Prescription Strength Cruex
- Vulvovaginal: Clotrimazole-3, Clotrimazole-7, Femcare, Gyne-Lotrimin, Gyne-Lotrimin 3 Day, Gyne-Lotrimin Combo Pack
- Oropharyngeal: Mycelex Troche

Adult Dosing

Topical
- Candidiasis, cutaneous
  - Apply bid
- Tinea
  - Apply bid
  - 2-4 weeks for best results with corporis, cruris, pedis, versicolor
Vulvovaginal
- candidiasis, vulvovaginal
  - 200mg PV qhs x3 days
  - Alt: 100mg PV qhs x7 days
  - Alt: 1 applicatorful 2% PV qhs x3 days
  - Alt: 1 applicatorful 1% PV qhs x7-14 days
Oropharyngeal
- candidiasis treatment, oropharyngeal
  - 10mg PO 5x/day x14 days
    - slowly dissolve in mouth; do not chew or swallow whole
- candidiasis prophylaxis, oropharyngeal
  - 10mg PO tid
    - continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole

Indications by Disease

Disease	Dose	Context
Balanoposthitis	1% applied topically to glans q12hrs until resolution	Antifungal
Candida vulvovaginitis	1% cream applied vaginally for 7 days OR 2% applied vaginally for 3 days	Intravaginal therapy
Oropharyngeal candidiasis	10 mg troches 5 times/day for 14 consecutive days	Adult

Pediatric Dosing

Same as adult

Indications by Disease

Disease	Dose	Context
Oropharyngeal candidiasis	10mg PO five times daily for 14 days	Pediatric (>3 years)

Special Populations

Pregnancy Rating: B (topical, vulvovaginal), C (oropharyngeal)
Lactation risk: Probably safe (topical, vulvovaginal), Safety unknown (oropharyngeal)

Renal Dosing

Adult:
Pediatric:

Hepatic Dosing

Adult: Precaution with troches. Monitor LFTs.
Pediatric:

Contraindications

Allergy to class/drug

Adverse Reactions

Serious

may occur but none reported

Common

Topical
- irritation
- burning/stinging
- pruritus
- erythema
- localized edema
- urticaria
- peeling
- blistering
Vulvovaginal
- vulvovaginal burning
- vulvovaginal pruritus
- vulvovaginal soreness
- vulvovaginal swelling
- pelvic pain
- pelvic cramps
- abdominal pain
Oropharyngeal
- vomiting
- nausea
- abdominal cramps
- abnormal LFTs

Pharmacology

Half-life: Unknown
Metabolism: liver; CYP450: unknown; Info: minimal systemic absorption
Excretion: bile/feces primarily, urine

Mechanism of Action

Exact mechanism of action unknown
Azole antifungal
- Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis and increasing cellular permeability

Comments

References

Authors:

@@ Line 1: / Line 1: @@
 ==Administration==
-*Type: Anti-fungal, azole
+*Type: [[Antifungal]], azole
 *Dosage Forms
 **Topical:1% cream
 **Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
-**Oropharyngeal: 10 mg troche
+**Oropharyngeal: 10mg troche
 *Routes of Administration: topical, oropharyngeal, vaginal
 *Common Trade Names
@@ Line 17: / Line 17: @@
 **Tinea
 ***Apply bid
-***2-4 wks for best results with corporis, cruris, pedis, versicolor
+***2-4 weeks for best results with corporis, cruris, pedis, versicolor
 *Vulvovaginal
 **candidiasis, vulvovaginal
-***200 mg PV qhs x3 days
+***200mg PV qhs x3 days
-***Alt: 100 mg PV qhs x7 days
+***Alt: 100mg PV qhs x7 days
 ***Alt: 1 applicatorful 2% PV qhs x3 days
 ***Alt: 1 applicatorful 1% PV qhs x7-14 days
 *Oropharyngeal
 **candidiasis treatment, oropharyngeal
-***10 mg PO 5x/day x14 days
+***10mg PO 5x/day x14 days
 ****slowly dissolve in mouth; do not chew or swallow whole
 **candidiasis prophylaxis, oropharyngeal
-***10 mg PO tid
+***10mg PO tid
 ****continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole
+===Indications by Disease===
+{{#ask: [[Has DrugName::Clotrimazole]] [[Has Population::Adult]]
+ |?Treats disease=Disease
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |format=table
+ |limit=50
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Pediatric Dosing==
 Same as adult
+===Indications by Disease===
+{{#ask: [[Has DrugName::Clotrimazole]] [[Has Population::Pediatric]]
+ |?Treats disease=Disease
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |format=table
+ |limit=50
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Special Populations==
@@ Line 83: / Line 108: @@
 *Azole antifungal
 **Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis and increasing cellular permeability
 ==Comments==
 ==See Also==
+*[[Antifungals]]
+*[[Fungal infections]]
 ==References==
@@ Line 91: / Line 119: @@
 *[https://online.epocrates.com/drugs/12/clotrimazole-topical Epocrates:clotrimazole-topical]
 *[https://online.epocrates.com/drugs/3416/clotrimazole-vaginal Epocrates: clotrimazole-vaginal]
+<references/>
-<references/>
 [[Category:Pharmacology]]
+[[Category:ID]]