Tamsulosin: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Alpha blocker *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Flomax ==Adult Dosing== *0.4mg PO once daily ==Pediatric Dosing==...") |
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==Administration== | ==Administration== | ||
*Type: | *Type: α-blocker | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*0.4mg PO once daily | *0.4mg PO once daily or nightly | ||
===[[Urolithiasis]]=== | |||
*0.4mg PO QHS until stone expulsion | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | ''Safety/efficacy not established'' | ||
| Line 23: | Line 27: | ||
===Serious=== | ===Serious=== | ||
*Retinal detachment | *Retinal detachment | ||
*Priapism | *[[Priapism]] | ||
===Common=== | ===Common=== | ||
*Headache, dizziness, insomnia, somnolence | *Headache, dizziness, insomnia, somnolence | ||
| Line 35: | Line 40: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
* | *α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate | ||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
*[[EBQ:Alpha-blockers for ureteral stone expulsion]] | *[[EBQ:Alpha-blockers for ureteral stone expulsion]] | ||
*[[Urolithiasis]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Urology]] | |||
Latest revision as of 12:18, 6 March 2021
Administration
- Type: α-blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Flomax
Adult Dosing
- 0.4mg PO once daily or nightly
Urolithiasis
- 0.4mg PO QHS until stone expulsion
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult: No adjustment for CrCl >10
Hepatic Dosing
- Adult: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Retinal detachment
- Priapism
Common
- Headache, dizziness, insomnia, somnolence
- Abnormal ejaculation
- Rhinitis
- Back pain
Pharmacology
- Half-life: 9-15h
- Metabolism: CYP3A4 and CYP2D6
- Excretion: Mostly renal
Mechanism of Action
- α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate