Paromomycin: Difference between revisions
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==Administration== | ==Administration== | ||
*Class:[[Is DrugClass::Aminoglycoside]] | |||
*Type: Amebicide | *Type: Amebicide | ||
*Dosage Forms: 250 | *Dosage Forms: 250 | ||
| Line 11: | Line 12: | ||
===[[Hepatic encephalopathy]]=== | ===[[Hepatic encephalopathy]]=== | ||
*adjunct treatment: | *adjunct treatment: 1000mg PO QID x5-6 days | ||
**Give with food | **Give with food | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Paromomycin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Paromomycin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
===Intestinal [[amebiasis]]=== | ===Intestinal [[amebiasis]]=== | ||
*25-35mg/kg/day PO divided tid x5-10 days | *25-35mg/kg/day PO divided tid x5-10 days | ||
| Line 67: | Line 92: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 20:38, 20 March 2026
Administration
- Class:Aminoglycoside
- Type: Amebicide
- Dosage Forms: 250
- Routes of Administration: Oral
- Common Trade Names: Humatin
Adult Dosing
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
- Give with food
Hepatic encephalopathy
- adjunct treatment: 1000mg PO QID x5-6 days
- Give with food
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Acute diarrhea | 500mg q8hrs for 7 days | Entamoeba, Luminal |
| Acute diarrhea | 500mg PO q8hrs x 14-28days | Cryptosporidium |
Pediatric Dosing
Indications by Disease
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
Special Populations
- Poorly absorbed when given orally
- Use during pregnancy has limited data
Renal Dosing
- No change in dosing
Hepatic Dosing
- No change in dosing
Contraindications
- Allergy to class/drug
- GI obstruction
- caution if ulcerative colitis
- caution if inflammatory bowel disease
- caution if renal impairment
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity, auditory
- ototoxicity, vestibular
- neurotoxicity
- neuromuscular blockade
- malabsorption syndrome (prolonged use)
- superinfection (prolonged use)
- enterocolitis
Common
Pharmacology
- Half-life: Unknown
- Metabolism: CYP450
- Excretion: Feces
Mechanism of Action
Bactericidal and amebicidal. Paromomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; it suppresses urease producing bacteria, reducing ammonia absorption from gut
Comments
See Also
References
UpToDate, Epocrates