Oxybutynin

Administration

• Type: Antispasmodic, urinary
• Dosage Forms: 5mg
• Routes of Administration: Oral
• Common Trade Names: Oxybutynin chloride

Adult Dosing

• 5mg 2-3 times daily, maximum 5mg 4 times daily

Pediatric Dosing

• > 5 years and adolescent
  • 5mg twice daily, maximum 5mg 3 times daily

Geriatric Dosing

• 2.5mg 2-3 times daily, increase cautiously

Special Populations

• Pregnancy Rating: B
• Lactation risk: Not defined, use with caution when administered to a nursing woman

Renal Dosing

• Adult: Not defined
• Pediatric: Not defined

Hepatic Dosing

• Adult: Not defined
• Pediatric: Not defined

Contraindications

• Allergy to class/drug
• Risk of narrow-angle glaucoma
• Risk of urinary retention
• Risk of gastric retention or severely decreased gastric motility

Adverse Reactions

Serious

• Arrhythmia (sinus)
• Hypotension
• Hypertension

Common

• Dizziness
• Drowsiness
• Xerostomia (dose-related)
• Constipation
• Nausea
• Headache
• Nervousness
• Insomnia
• Urinary hesitancy
• Urinary retention
• Urinary tract infection
• Blurred vision

Pharmacology

• Half-life: 2-3 h
• Metabolism: Liver
• Excretion: Urine

Mechanism of Action

• Direct antispasmodic effect on smooth muscle
• Inhibit action of acetylcholine on smooth muscle; decreased frequency and urgent