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| ==Markers== | | ==Types== |
| | | {{Cardiac enzyme timecourse chart}} |
| {| class="pbNotSortable" width="300" cellspacing="1" cellpadding="1" | |
| | Name
| |
| | INTL
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| | ELV PEAK
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| | RETRN
| |
| |-
| |
| | myglbn
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| | 1-4h
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| | 6-7h
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| | 18-24h
| |
| |-
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| | trp I
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| | 3-12
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| | 10-24
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| | 3-10d
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| |-
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| | trp T
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| | 3-12
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| | 10-24
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| | 5-14d
| |
| |-
| |
| | ckmb
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| | 4-12
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| | 12-24
| |
| | 48-72
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| |-
| |
| | ldh
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| | 8-12
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| | 24-48
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| | 10-14d
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| |}
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">n I - �2-4 hrs 1st detect</font></font></span>
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| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �8-12 hrs w/100% sensitivity</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �10-24 peak</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �5-10 day duration</font></font></span>
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| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">Tn T - above plus 5-14 d duration</font></font></span>
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| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">CK-MB : �3-4</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � 8-12 (100% sensitive)</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � �10-24 hr peak</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">MYOGLOBIN : 1-2 hrs detect first</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � �4-8 100% sens</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � � 4-8 peak</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � � 0.5-1.0 duration</font></font></span>
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| | |
| <span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � 2-4 day duration</font></font></span>
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| ==Creatine Phosphokinase== | | ==Creatine Phosphokinase== |
| | | *Can be elevated in trauma, [[rhabdomyolysis]], hyperthermia, physical activity, renal or endocrine disease, systemic infections |
| -can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections
| | *If patient small with small muscle mass to begin with, total ck may not be elevated- so better to use CK index- is ratio of CKMB/ total CK. Elevated if > 3- 5%. |
| | | *CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of AMI |
| -if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.
| | *CK-MB can be removed from the routine ED cardiac panel without adversely affecting patient care<ref>Le RD, Kosowsky JM, Landman AB, et al. Clinical and financial impact of removing creatine kinase-MB from the routine testing menu in the emergency setting. Am J Emerg Med. 2015;33(1):72–5. </ref> |
| | |
| -CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami
| |
| | |
| ==Troponins==
| |
| | |
| -during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction. | |
| | |
| -troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does. | |
| | |
| -troponin C found in all tissue and is not cardiac marker
| |
| | |
| -troponin T is qualitative assay.
| |
| | |
| -troponin I is quantitative assay.
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|
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| ==See Also== | | ==See Also== |
| | *[[Troponin]] |
| | *[[Acute Coronary Syndrome (Main)]] |
|
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|
| Cards: CK-MB
| | ==References== |
| | | <references/> |
| Cards: Troponin
| |
| | |
| | |
| == Markers == | |
| | |
| Name INTL ELV PEAK RETRN myglbn 1-4h 6-7h 18-24h trp I 3-12 10-24 3-10d trp T 3-12 10-24 5-14d ckmb 4-12 12-24 48-72 ldh 8-12 24-48 10-14d
| |
| | |
| <br/>n I - 2-4 hrs 1st detect | |
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| 8-12 hrs w/100% sensitivity
| |
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| 10-24 peak
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| 5-10 day duration
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| Tn T - above plus 5-14 d duration
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| CK-MB : 3-4
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| 8-12 (100% sensitive)
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| 10-24 hr peak
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| MYOGLOBIN : 1-2 hrs detect first
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| 4-8 100% sens
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| 4-8 peak
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| 0.5-1.0 duration
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| 2-4 day duration
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| == Creatine Phosphokinase ==
| |
| | |
| -can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections
| |
| | |
| -if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.
| |
| | |
| -CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami
| |
| | |
| | |
| | |
| == Troponins ==
| |
| | |
| -during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
| |
| | |
| -troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
| |
| | |
| -troponin C found in all tissue and is not cardiac marker
| |
| | |
| -troponin T is qualitative assay.
| |
| | |
| -troponin I is quantitative assay.
| |
| | |
| | |
| | |
| == See Also ==
| |
| | |
| Cards: CK-MB
| |
| | |
| Cards: Troponin
| |
|
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|
| <br/>[[Category:Cards]]
| | [[Category:Cardiology]] |
