Ribavarin: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: Antiviral- FDA approved for Hepatitis C, severe RSV infection. Off-label use: herpes simplex, influenza, viral hemorrhagic fever | *Type: Antiviral- FDA approved for [[Hepatitis C]], severe [[RSV]] infection. Off-label use: [[herpes simplex]], [[influenza]], [[viral hemorrhagic fever]] | ||
*Dosage Forms: | *Dosage Forms: 200 tab, 200 cap | ||
*Routes of Administration: Oral, inhalation | *Routes of Administration: Oral, inhalation | ||
*Common Trade Names: | *Common Trade Names: Copegus, Rebetol, Ribasphere | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 17:23, 28 September 2016
Administration
- Type: Antiviral- FDA approved for Hepatitis C, severe RSV infection. Off-label use: herpes simplex, influenza, viral hemorrhagic fever
- Dosage Forms: 200 tab, 200 cap
- Routes of Administration: Oral, inhalation
- Common Trade Names: Copegus, Rebetol, Ribasphere
Adult Dosing
- 200-1000mg daily (dose depends on genotype and concurrent treatment with interferon)
Pediatric Dosing
- Hep C: >2 years old: 15mg/kg daily OR 400-1200mg daily
- RSV (severe cases): 20mg/ml aerosolized over 12-18 hours x 3-7 days
Special Populations
- Pregnancy Rating: X
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: reduced doses for mild-moderate impairment, do not use if CrCl <50
Contraindications
- Allergy to class/drug
- Autoimmune hepatitis
- Coadministration with didanosine
- Hemoglobinopathy (e.g. thalassemia, sickle cell)
- Pregnant or potentially pregnant women, men who may impregnate someone
- Renal impairment (CrCl <50)
Adverse Reactions
Serious
- Hemolytic anemia, TTP
- Bacterial disease
- Hepatotoxicity
- MI
- Suicide
Common
- Neutropenia
- Nausea, vomiting, diarrhea
- Asthenia, dizziness, fatigue
- Weight loss
- Pruritus
Pharmacology
- Half-life: ~300 hours
- Metabolism:
- Excretion: Mostly renal
Mechanism of Action
- Mechanism not well understood