Carbamazepine toxicity: Difference between revisions
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==Background== | ==Background== | ||
*Has anticholinergic | *Has [[Anticholinergic Toxicity|anticholinergic]] and antiepileptic effects | ||
*Therapeutic concentration: 4-12 | *Therapeutic concentration: 4-12 | ||
Revision as of 13:26, 7 February 2014
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic toxidrome
- CV
- Dysrhythmias are rare but may occur
- Widened QRS
- QT prolongation
Diagnosis
- Levels do not accurately correlate w/ clinical severity
Treatrment
- GI detox
- Activated charcoal (if presents w/in 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider d/c for pt with decreasing levels (measured few hrs apart) and is asymptomatic
Source
- Tintinalli