Bupropion toxicity: Difference between revisions
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==Evaluation== | ==Evaluation== | ||
*CBC, CMP | *CBC, CMP | ||
*ECG to eval for QT prolongation | *ECG to eval for [[QT prolongation]] | ||
==Management== | ==Management== | ||
Revision as of 11:14, 6 November 2016
Background
- Uses
- Antidepressant
- Smoking cessation
- ADHD
- Inhibits reuptake of norepinephrine and dopamine
- Toxicity occurs with ingestion of >450mg/d
Clinical Features
- Agitation
- Dizziness
- Tremor
- Nausea/vomiting
- Drowsiness
- Tachycardia
- Seizure
- May develop in isolation from other symptoms
- Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms
- Hypotension and Cardiogenic Shock
Differential Diagnosis
Evaluation
- CBC, CMP
- ECG to eval for QT prolongation
Management
- GI decontamination
- Consider whole-bowel irrigation for sustained-release formulations
- Seizure Treatment
- Benzos are 1st line
- Barbituates are 2nd line
Disposition
- Consider discharge if asymptomatic after 8hr for regular-release ingestions