Lichen sclerosus: Difference between revisions
| Line 12: | Line 12: | ||
==Evaluation== | ==Evaluation== | ||
*Biopsy — A 4 mm vulvar punch biopsy typically provides sufficient tissue to confirm the diagnosis and to evaluate for atypical histologic features | |||
*Histopathology — On histologic examination, the epidermis is typically thinned, although areas of hyperkeratosis may be observed, and early lesions may demonstrate mild, irregular epidermal acanthosis | |||
*Clinical judgment should guide the diagnosis and treatment of LS when biopsy results are not specific | |||
==Management== | ==Management== | ||
Revision as of 00:24, 29 November 2016
Background
- A benign, chronic, progressive dermatologic condition characterized by marked inflammation, epithelial thinning, and distinctive dermal changes accompanied by symptoms of pruritus and pain
- Typically affects postmenopausal women, however it does sometimes occur in men, children, and premenopausal women
- Thought to be related to low estrogen states
Clinical Features
- Skin becomes thin, wrinkles, and whitened
- Most common symptoms include itching and pain at the affected areas, most commonly the clitoris and labia (although any skin surface can be affected)
- Other symptoms include anal discomfort, dyspareunia, and dysuria
Differential Diagnosis
Evaluation
- Biopsy — A 4 mm vulvar punch biopsy typically provides sufficient tissue to confirm the diagnosis and to evaluate for atypical histologic features
- Histopathology — On histologic examination, the epidermis is typically thinned, although areas of hyperkeratosis may be observed, and early lesions may demonstrate mild, irregular epidermal acanthosis
- Clinical judgment should guide the diagnosis and treatment of LS when biopsy results are not specific