Hodgkin's lymphoma: Difference between revisions
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==Background== | ==Background== | ||
*Spreads from source lymph node to adjacent nodes | *Spreads from source lymph node to adjacent nodes | ||
* | *May be related to viral infections | ||
*More common in males | *More common in males | ||
*Bimodal distribution: young adulthood and older aged | *Bimodal distribution: young adulthood and older aged | ||
*Most common malignancy | *Most common malignancy in 15-19 year olds | ||
*Survival >90% in low-risk patients | *Survival >90% in low-risk patients | ||
==Clinical Features== | ==Clinical Features== | ||
*Painless, firm, lymph node (usually cervical or supraclavicular) | *Painless, firm, [[lymphadenopathy|lymph node]] (usually cervical or supraclavicular) | ||
*"B" symptoms: fever, night sweats, | *"B" symptoms: [[fever]], night sweats, weight loss | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
| Line 18: | Line 18: | ||
==Evaluation== | ==Evaluation== | ||
*[[CXR]] | *[[CXR]] | ||
*CT neck/ | *CT neck/chest/abdomen/pelvis | ||
* | *Lymph node biopsy | ||
**Reed-Sternberg cells next to normal lymphocytes | **Reed-Sternberg cells next to normal lymphocytes | ||
==Management== | ==Management== | ||
*Manage acute complications | *Manage acute complications | ||
**Superior vena cava syndrome | **[[Superior vena cava syndrome]] | ||
**Upper airway compression | **Upper airway compression | ||
***Do NOT give steroids | ***Do NOT give steroids (''citation/rationale?'') | ||
**[[Tumor lysis syndrome]] | |||
**[[Neutropenic fever]] | |||
**Chemo-induced [[nausea/vomiting]] | |||
==See Also== | ==See Also== | ||
Revision as of 01:22, 11 December 2016
Background
- Spreads from source lymph node to adjacent nodes
- May be related to viral infections
- More common in males
- Bimodal distribution: young adulthood and older aged
- Most common malignancy in 15-19 year olds
- Survival >90% in low-risk patients
Clinical Features
- Painless, firm, lymph node (usually cervical or supraclavicular)
- "B" symptoms: fever, night sweats, weight loss
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Evaluation
- CXR
- CT neck/chest/abdomen/pelvis
- Lymph node biopsy
- Reed-Sternberg cells next to normal lymphocytes
Management
- Manage acute complications
- Superior vena cava syndrome
- Upper airway compression
- Do NOT give steroids (citation/rationale?)
- Tumor lysis syndrome
- Neutropenic fever
- Chemo-induced nausea/vomiting