Cardiac enzymes: Difference between revisions

(Created page with "==Markers== Name INTL ELV PEAK RETRN myglbn 1-4h 6-7h 18-24h trp I 3-12 10-24 3-10d trp T 3-12 10-24 5-14d ckmb 4-12 12-24 48-72 ldh 8-12 24-48 10-14d n I - 2-4 hrs 1...")
 
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==Markers==
==Markers==


{| class="pbNotSortable" width="300" cellspacing="1" cellpadding="1"
| Name
| INTL
| ELV PEAK
| RETRN
|-
| myglbn
| 1-4h
| 6-7h
| 18-24h
|-
| trp I
| 3-12
| 10-24
| 3-10d
|-
| trp T
| 3-12
| 10-24
| 5-14d
|-
| ckmb
| 4-12
| 12-24
| 48-72
|-
| ldh
| 8-12
| 24-48
| 10-14d
|}


Name INTL ELV PEAK RETRN
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">n I - �2-4 hrs 1st detect</font></font></span>
myglbn 1-4h 6-7h 18-24h
trp I 3-12 10-24 3-10d
trp T 3-12 10-24 5-14d
ckmb 4-12 12-24 48-72
ldh 8-12 24-48 10-14d


n I - 2-4 hrs 1st detect
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �8-12 hrs w/100% sensitivity</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �10-24 peak</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � �5-10 day duration</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">Tn T - above plus 5-14 d duration</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">CK-MB : �3-4</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � 8-12 (100% sensitive)</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � �10-24 hr peak</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">MYOGLOBIN : 1-2 hrs detect first</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � �4-8 100% sens</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � � 4-8 peak</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � � � � � � � 0.5-1.0 duration</font></font></span>
 
<span class="Apple-style-span" style="line-height: normal; border-collapse: collapse"><font face="arial"><font color="#000000">� � � � � � � � � 2-4 day duration</font></font></span>
 
==Creatine Phosphokinase==
 
-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections
 
-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.
 
-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami
 
==Troponins==
 
-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
 
-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
 
-troponin C found in all tissue and is not cardiac marker
 
-troponin T is qualitative assay.
 
-troponin I is quantitative assay.
 
==See Also==
 
Cards: CK-MB
 
Cards: Troponin
 
 
== Markers ==
 
Name INTL ELV PEAK RETRN myglbn 1-4h 6-7h 18-24h trp I 3-12 10-24 3-10d trp T 3-12 10-24 5-14d ckmb 4-12 12-24 48-72 ldh 8-12 24-48 10-14d
 
<br/>n I - 2-4 hrs 1st detect


           8-12 hrs w/100% sensitivity
           8-12 hrs w/100% sensitivity
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Tn T - above plus 5-14 d duration
Tn T - above plus 5-14 d duration


CK-MB : 3-4
CK-MB&nbsp;: 3-4


                   8-12 (100% sensitive)
                   8-12 (100% sensitive)
Line 26: Line 106:
                 10-24 hr peak
                 10-24 hr peak


MYOGLOBIN : 1-2 hrs detect first
MYOGLOBIN&nbsp;: 1-2 hrs detect first


                             4-8 100% sens
                             4-8 100% sens
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                   2-4 day duration
                   2-4 day duration




==Creatine Phosphokinase==


== Creatine Phosphokinase ==


-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections
-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections


-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.
-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.


-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami
-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami




==Troponins==


== Troponins ==


-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.


-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.


-troponin C found in all tissue and is not cardiac marker
-troponin C found in all tissue and is not cardiac marker
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-troponin I is quantitative assay.
-troponin I is quantitative assay.




==See Also==


== See Also ==


Cards: CK-MB
Cards: CK-MB
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Cards: Troponin
Cards: Troponin


 
<br/>[[Category:Cards]]
 
 
[[Category:Cards]]

Revision as of 04:21, 12 March 2011

Markers

Name INTL ELV PEAK RETRN
myglbn 1-4h 6-7h 18-24h
trp I 3-12 10-24 3-10d
trp T 3-12 10-24 5-14d
ckmb 4-12 12-24 48-72
ldh 8-12 24-48 10-14d

n I - �2-4 hrs 1st detect

� � � � � �8-12 hrs w/100% sensitivity

� � � � � �10-24 peak

� � � � � �5-10 day duration

Tn T - above plus 5-14 d duration

CK-MB : �3-4

� � � � � � � � � 8-12 (100% sensitive)

� � � � � � � � �10-24 hr peak

MYOGLOBIN : 1-2 hrs detect first

� � � � � � � � � � � � � � �4-8 100% sens

� � � � � � � � � � � � � � � 4-8 peak

� � � � � � � � � � � � � � � 0.5-1.0 duration

� � � � � � � � � 2-4 day duration

Creatine Phosphokinase

-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections

-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.

-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami

Troponins

-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.

-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.

-troponin C found in all tissue and is not cardiac marker

-troponin T is qualitative assay.

-troponin I is quantitative assay.

See Also

Cards: CK-MB

Cards: Troponin


Markers

Name INTL ELV PEAK RETRN myglbn 1-4h 6-7h 18-24h trp I 3-12 10-24 3-10d trp T 3-12 10-24 5-14d ckmb 4-12 12-24 48-72 ldh 8-12 24-48 10-14d


n I - 2-4 hrs 1st detect 

          8-12 hrs w/100% sensitivity

          10-24 peak

          5-10 day duration

Tn T - above plus 5-14 d duration

CK-MB : 3-4 

                 8-12 (100% sensitive)

                10-24 hr peak

MYOGLOBIN : 1-2 hrs detect first 

                            4-8 100% sens

                             4-8 peak

                             0.5-1.0 duration

                 2-4 day duration


Creatine Phosphokinase

-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections

-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.

-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami


Troponins

-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.

-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.

-troponin C found in all tissue and is not cardiac marker

-troponin T is qualitative assay.

-troponin I is quantitative assay.


See Also

Cards: CK-MB

Cards: Troponin


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