Ceftolozane/tazobactam: Difference between revisions

Latest revision as of 18:17, 12 July 2017

Safety/efficacy not established in children

Pregnancy Rating: B
Lactation: Infant risk cannot be ruled out
Renal Dosing: 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
Hepatic Dosing: no adjustment

Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis
Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases

Authors:

@@ Line 1: / Line 1: @@
 ==General==
-*Type: Antibiotic (cephalosporin/beta-lactamase inhibitor combination)
+*Type: [[Antibiotic]] (cephalosporin/beta-lactamase inhibitor combination)
 *Dosage Forms: IV
 *Common Trade Names: Zerbaxa
@@ Line 8: / Line 8: @@
 ==Pediatric Dosing==
-N/A
+''Safety/efficacy not established in children''
 ==Special Populations==
 *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
-*Lactation:
+*Lactation: Infant risk cannot be ruled out
-*Renal Dosing
+*Renal Dosing: 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
-**Adult - 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
+*Hepatic Dosing: no adjustment
-**Pediatric - N/A
-*Hepatic Dosing
-**Adult - N/A
-**Pediatric - N/A
 ==Contraindications==
@@ Line 25: / Line 21: @@
 ==Adverse Reactions==
 ===Serious===
+*C. difficile diarrhea
+*Renal impairment
+*Hypersensitivity
 ===Common===
+*Nausea, diarrhea
+*Headache
+*Fever
 ==Pharmacology==
-*Half-life:
+*Half-life: Ceftolozane- ~3h, Tazobactam- ~1h
 *Metabolism: N/A
 *Excretion: Renal (100%)
-*Mechanism of Action:
+==Mechanism of Action==
+*Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis
+*Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases
 [[Category:ID]]