Drug induced aseptic meningitis: Difference between revisions
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**[[Isoniazid]] | **[[Isoniazid]] | ||
**[[Ciprofloxacin]] | **[[Ciprofloxacin]] | ||
**[[Amoxicillin]] | |||
**[[Gentamicin]] | |||
**[[Penicillin]] | **[[Penicillin]] | ||
**[[Metronidazole]] | **[[Metronidazole]] | ||
**[[ | **[[Cephalosporins]] | ||
**[[Pyrazinamide]] | **[[Pyrazinamide]] | ||
*IVIGs | *Immunoregulating agents | ||
*OKT3 monoclonal antibodies | **IVIGs | ||
**OKT3 monoclonal antibodies | |||
*Misc | |||
**[[Sulfasalazine]] | |||
**[[Carbamazepine]] | |||
**[[Azathioprine]] | |||
**Indinavir | |||
**[[Valacyclovir]] | |||
**[[Ranitidine]] | |||
**[[Famotidine]] | |||
**[[Methylprednisolone acetate]] | |||
**[[Allopurinol]] | |||
==Clinical presentation== | ==Clinical presentation== | ||
*[[Headache]] | *[[Headache]] | ||
Revision as of 18:07, 1 September 2017
Background
- Abbreviation: DIAM
- Two proposed mechanisms
- Direct meningeal irritation by intrathecal drug
- Hypersensitivity reaction to drug (type III and IV)
Causes
- NSAIDs
- Antibiotics
- Immunoregulating agents
- IVIGs
- OKT3 monoclonal antibodies
- Misc
Clinical presentation
- Headache
- Fever
- Nuchal rigidity
- Nausea/vomiting
- General malaise
- Less common symptoms include rash, arthralgia, myalgia, facial edema