Cefprozil: Difference between revisions
(→Administration: edited dosage forms, strengths, routes of administration) |
(→Pharmacology: edited metabolism, excretion, mechanism of action) |
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: 1.3 h | *Half-life: 1.3 h | ||
*Metabolism: | *Metabolism: hepatic | ||
*Excretion: urine | *Excretion: unchanged in urine (61%) | ||
*Mechanism of Action: inhibits bacterial cell wall synthesis | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
Revision as of 18:10, 13 October 2017
Administration
- Type: 2nd generation cephalosporin
- Dosage Forms: tablet, oral suspension
- Dosage Strengths: tablet: 250mg, 500mg; oral suspension: 125mg/5mL, 250mg/5mL
- Routes of Administration: PO
- Common Trade Names: Cefzil
Adult Dosing
Infections, bacterial:
- 250-500mg PO q12h x 10 days
Pediatric Dosing
infections, bacterial:
- 30mg/kg/day PO divided q12h x 10 days, max 1000mg/day
Special Populations
- Pregnancy Rating: B
- Lactation risk: probably safe
Renal Dosing
- Adult: CrCl < 30: decrease dose 50%
- Pediatric:CrCl < 30: decrease dose 50%
Hepatic Dosing
- Adult: none defined
- Pediatric: none defined
Contraindications
- Allergy to class/drug
- PKU
Adverse Reactions
Serious
- anaphylaxis
- seizures
- nephrotoxicity
- leukopenia or thrombocytopenia
- steven-johnson syndrome
- c-diff associated diarrhea
Common
- nausea
- diarrhea
- vomiting
- transaminitis
- dizziness
- rash
- eosinophilia
Pharmacology
- Half-life: 1.3 h
- Metabolism: hepatic
- Excretion: unchanged in urine (61%)
- Mechanism of Action: inhibits bacterial cell wall synthesis
Mechanism of Action
bactericidal, inhibits cell wall mucopeptide synthesis