Penicillin G Benzathine

General

• Type: Penicillin, a type of Penicillin G
• Dosage Forms: IM
• Common Trade Names: Bicillin L-A

Adult Dosing

Strep Pharyngitis

• 1.2 million units IM x 1

Syphilis

• Primary, secondary, or latent <1yr
  • 2.4 million units IM x 1
• Latent >1yr or unknown duration, or tertiary
  • 2.4 million units IM qWeek x 3 weeks

Rheumatic Fever Prophylaxis, Secondary

• 1.2 million units IM ever 4 weeks

Pediatric Dosing

Strep Pharyngitis

• <27kg: 0.6 million units IM x 1
• >27kg: 1.2 million units IM x 1

Syphilis

• Congenital (<1mo)
  • 50,000 units/kg IM x 1
  • Max: 2.4 million units/dose
  • Info: For asymptomatic disease only
• Acquired
  • Primary, secondary, or latent <1yr
    • 50,000 units/kg IM x 1
    • Max: 2.4 million units/dose
  • Latent >1yr or unknown duration
    • 50,000 units/kg IM qWeek x 3 weeks
    • Max: 2.4 million units/dose

Rheumatic Fever Prophylaxis, Secondary

• <27kg: 0.6 million units IM every 4 weeks
• >27kg: 1.2 million units IM every 4 weeks

Special Populations

• Pregnancy:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Penicillin G
• Antibiotics (Main)