Penicillin G Benzathine: Difference between revisions
| Line 72: | Line 72: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | |||
*[[Hypersensitivity Reaction]] | |||
*Exfoliative dermatitis | |||
*[[Steven-Johnson Syndrome]] | |||
===Common=== | ===Common=== | ||
Revision as of 12:53, 27 March 2014
General
- Type: Penicillin, a type of Penicillin G
- Dosage Forms: IM
- Common Trade Names: Bicillin L-A
Adult Dosing
Strep Pharyngitis
- 1.2 million units IM x 1
Syphilis
- Primary, secondary, or latent <1yr
- 2.4 million units IM x 1
- Latent >1yr or unknown duration, or tertiary
- 2.4 million units IM qWeek x 3 weeks
Rheumatic Fever Prophylaxis, Secondary
- 1.2 million units IM ever 4 weeks
Pediatric Dosing
Strep Pharyngitis
- <27kg: 0.6 million units IM x 1
- >27kg: 1.2 million units IM x 1
Syphilis
- Congenital (<1mo)
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Info: For asymptomatic disease only
- Acquired
- Primary, secondary, or latent <1yr
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Latent >1yr or unknown duration
- 50,000 units/kg IM qWeek x 3 weeks
- Max: 2.4 million units/dose
- Primary, secondary, or latent <1yr
Rheumatic Fever Prophylaxis, Secondary
- <27kg: 0.6 million units IM every 4 weeks
- >27kg: 1.2 million units IM every 4 weeks
Special Populations
- Pregnancy: B
- Lactation: Safe
- Renal Dosing
- Adult
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give after dialysis without supplement
- Peritoneal Dialysis: decrease dose 50-80%
- Pediatric
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give supplement
- Adult
- Hepatic Dosing (Adult & Pediatric)
- No data
Black Box
- Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)
Contraindications
- Allergy to class/drug
- Anaphylactic reaction to Beta Lactams
Cautions
- Non-anaphylactic reaction to Beta Lactams
- Hypersensitivity to multiple compounds
- Asthma
- Recent antibiotic associated colitis
- Seizure disorder
- Renal imparement
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity Reaction
- Exfoliative dermatitis
- Steven-Johnson Syndrome
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: