Template:Appendicitis Antibiotics: Difference between revisions
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''Coverage should extend to [[E. coli]], [[Klebsiella]], [[Proteus]], and [[Bacteroides]] (an anaerobe)'' | <languages/> | ||
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''Coverage should extend to [[Special:MyLanguage/E. coli|E. coli]], [[Special:MyLanguage/Klebsiella|Klebsiella]], [[Special:MyLanguage/Proteus|Proteus]], and [[Special:MyLanguage/Bacteroides|Bacteroides]] (an anaerobe)'' | |||
====Adult Simple Appendicitis==== | ====Adult Simple Appendicitis==== | ||
''Antibiotic prophylaxis should be coordinated with surgical consult'' | ''Antibiotic prophylaxis should be coordinated with surgical consult'' | ||
'''Options:''' | '''Options:''' | ||
*[[Cefoxitin]] 2g IV q6 hours OR | *[[Special:MyLanguage/Cefoxitin|Cefoxitin]] 2g IV q6 hours OR | ||
*[[Cefotetan]] 2g IV q12 hours OR | *[[Special:MyLanguage/Cefotetan|Cefotetan]] 2g IV q12 hours OR | ||
*[[Moxifloxacin]] 400mg IV once daily OR | *[[Special:MyLanguage/Moxifloxacin|Moxifloxacin]] 400mg IV once daily OR | ||
*[[Ertapenem]] 1g IV once daily | *[[Special:MyLanguage/Ertapenem|Ertapenem]] 1g IV once daily | ||
====Pediatric Simple Appendicitis==== | ====Pediatric Simple Appendicitis==== | ||
'''Options:''' | '''Options:''' | ||
*[[Cefoxitin]] 40mg/kg IV q6 hours | *[[Special:MyLanguage/Cefoxitin|Cefoxitin]] 40mg/kg IV q6 hours | ||
*[[Cefotetan]] 40mg/kg IV q12 hours | *[[Special:MyLanguage/Cefotetan|Cefotetan]] 40mg/kg IV q12 hours | ||
*[[Gentamicin]] 2.5mg/kg IV q8hrs + | *[[Special:MyLanguage/Gentamicin|Gentamicin]] 2.5mg/kg IV q8hrs + | ||
**[[Metronidazole]] 7.5mg/kg IV 16hrs OR | **[[Special:MyLanguage/Metronidazole|Metronidazole]] 7.5mg/kg IV 16hrs OR | ||
**[[Clindamycin]] 10mg/kg IV q8hrs | **[[Special:MyLanguage/Clindamycin|Clindamycin]] 10mg/kg IV q8hrs | ||
====Complicated Appendicitis==== | ====Complicated Appendicitis==== | ||
''Defined as perforation, abscess, or phlegmon'' | ''Defined as perforation, abscess, or phlegmon'' | ||
'''Options:''' | '''Options:''' | ||
*[[Metronidazole]] 500 mg IV q8hrs + | *[[Special:MyLanguage/Metronidazole|Metronidazole]] 500 mg IV q8hrs + | ||
**[[Cefepime]] 50 mg/kg IV q12hrs OR | **[[Special:MyLanguage/Cefepime|Cefepime]] 50 mg/kg IV q12hrs OR | ||
**[[Ciprofloxacin]] 400 mg IV q12hrs OR | **[[Special:MyLanguage/Ciprofloxacin|Ciprofloxacin]] 400 mg IV q12hrs OR | ||
**[[Levofloxacin]] 750 mg IV q24hrs OR | **[[Special:MyLanguage/Levofloxacin|Levofloxacin]] 750 mg IV q24hrs OR | ||
**[[Aztreonam]] 30 mg/kg IV q8hrs | **[[Special:MyLanguage/Aztreonam|Aztreonam]] 30 mg/kg IV q8hrs | ||
*[[Imipenem/Cilastatin]] 25 mg/kg IV q6hrs (max 500mg) | *[[Special:MyLanguage/Imipenem/Cilastatin|Imipenem/Cilastatin]] 25 mg/kg IV q6hrs (max 500mg) | ||
*[[Meropenem]] 20 mg/kg IV q8hrs (max 1g) | *[[Special:MyLanguage/Meropenem|Meropenem]] 20 mg/kg IV q8hrs (max 1g) | ||
*[[Piperacillin/Tazobactam]] 100 mg/kg (max 4.5g) IV q8hrs | *[[Special:MyLanguage/Piperacillin/Tazobactam|Piperacillin/Tazobactam]] 100 mg/kg (max 4.5g) IV q8hrs | ||
''Cautious use should be applied to use of [[fluoroquinolones]] in complicated pediatric appendicitis due to the risk of tendon injury'' | ''Cautious use should be applied to use of [[Special:MyLanguage/fluoroquinolones|fluoroquinolones]] in complicated pediatric appendicitis due to the risk of tendon injury'' | ||
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Revision as of 10:42, 23 January 2026
Coverage should extend to E. coli, Klebsiella, Proteus, and Bacteroides (an anaerobe)
Adult Simple Appendicitis
Antibiotic prophylaxis should be coordinated with surgical consult
Options:
- Cefoxitin 2g IV q6 hours OR
- Cefotetan 2g IV q12 hours OR
- Moxifloxacin 400mg IV once daily OR
- Ertapenem 1g IV once daily
Pediatric Simple Appendicitis
Options:
- Cefoxitin 40mg/kg IV q6 hours
- Cefotetan 40mg/kg IV q12 hours
- Gentamicin 2.5mg/kg IV q8hrs +
- Metronidazole 7.5mg/kg IV 16hrs OR
- Clindamycin 10mg/kg IV q8hrs
Complicated Appendicitis
Defined as perforation, abscess, or phlegmon
Options:
- Metronidazole 500 mg IV q8hrs +
- Cefepime 50 mg/kg IV q12hrs OR
- Ciprofloxacin 400 mg IV q12hrs OR
- Levofloxacin 750 mg IV q24hrs OR
- Aztreonam 30 mg/kg IV q8hrs
- Imipenem/Cilastatin 25 mg/kg IV q6hrs (max 500mg)
- Meropenem 20 mg/kg IV q8hrs (max 1g)
- Piperacillin/Tazobactam 100 mg/kg (max 4.5g) IV q8hrs
Cautious use should be applied to use of fluoroquinolones in complicated pediatric appendicitis due to the risk of tendon injury