Neuroblastoma (peds): Difference between revisions
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**[[Horner syndrome]] | **[[Horner syndrome]] | ||
**Spinal cord compression | **Spinal cord compression | ||
*Opsoclonus-myoclonus | *[[Opsoclonus]]-myoclonus | ||
** | **[[paraneoplastic]] syndrome highly associated with neuroblastoma | ||
*Neutropenia/pancytopenia suggests bone marrow involvement | *[[Neutropenia]]/[[pancytopenia]] suggests bone marrow involvement | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==Evaluation== | ==Evaluation== | ||
*CT or MRI | |||
*[[CXR]] | *[[CXR]] | ||
*Biopsy for definitive diagnosis | |||
==Management== | ==Management== | ||
* | *Admission for tumor biopsy | ||
==See Also== | ==See Also== | ||
Revision as of 05:07, 1 October 2019
Background
- Arises from primitive ganglion cells of sympathetic nervous system
- Most common neoplasm in 1st yr of life
- May arise anywhere along sympathetic nervous system
- Adrenal gland (40%)
- Abdomen (25%)
- Chest (15%)
Clinical Features
- Depends on location
- Large, painless abdominal mass
- Compression of bowel/bladder
- Horner syndrome
- Spinal cord compression
- Opsoclonus-myoclonus
- paraneoplastic syndrome highly associated with neuroblastoma
- Neutropenia/pancytopenia suggests bone marrow involvement
Differential Diagnosis
- Wilms' tumor
- Other adrenal gland tumor
Evaluation
- CT or MRI
- CXR
- Biopsy for definitive diagnosis
Management
- Admission for tumor biopsy