Ketoconazole: Difference between revisions
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*Dosage Forms: Tablet, 200mg | *Dosage Forms: Tablet, 200mg | ||
*Routes of Administration: PO, topical | *Routes of Administration: PO, topical | ||
*Common Trade Names: | *Common Trade Names: Nizoral | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 03:19, 8 March 2021
Administration
- Type: Antifungal
- Dosage Forms: Tablet, 200mg
- Routes of Administration: PO, topical
- Common Trade Names: Nizoral
Adult Dosing
Fungal infections
- 200-400mg PO qday
Prostate cancer
- 400mg PO q8h
Pediatric Dosing
Fungal infectionss (2 years and up)
- 3.3-6.6mg/kg PO qday
Special Populations
- Pregnancy Rating: C, adverse events have been seen in animal studies
- Lactation risk: Excreted in breast milk, not recommended by manufacturer.
Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
Hepatic Dosing
- Adult: contraindicated in liver disease
- Pediatric: contraindicated in liver disease
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hepatotoxicity
- Adrenal insufficiency
- Hypersensitivity reaction
- Anaphylaxis
- Thrombocytopenia
- Leukopenia
- Hemolytic anemia
Common
Pharmacology
- Half-life: 8 h
- Metabolism: Liver (CYP450)
- Excretion: feces > urine
Mechanism of Action
- Inhibits synthesis of cell membrane ergosterol