Hydrocortisone/neomycin/polymyxin: Difference between revisions
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(Add AntibioticDose SMW query table for dynamic indications by disease) |
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*4 drops in ear q6-8hr | *4 drops in ear q6-8hr | ||
*Max: 10 days | *Max: 10 days | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Hydrocortisone/neomycin/polymyxin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*3 drops in ear q6-8hr | *3 drops in ear q6-8hr | ||
*Max: 10 days | *Max: 10 days | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Hydrocortisone/neomycin/polymyxin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
Latest revision as of 20:38, 20 March 2026
Administration
- Type: topical antibiotic/steroid
- Dosage Forms: 3.5 mg/10,000 units/10 mg per mL
- Routes of Administration: topical, otic
- Common Trade Names: Cortisporin otic
Adult Dosing
- 4 drops in ear q6-8hr
- Max: 10 days
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Otitis externa | 4 drops in ear TID-QID x 7days | Topical |
Pediatric Dosing
- 3 drops in ear q6-8hr
- Max: 10 days
Indications by Disease
Special Populations
- Pregnancy Rating: Category C
- Lactation risk: Unknown whether drug is excreted in milk; use with caution
Renal Dosing
- Adult: n/a
- Pediatric: n/a
Hepatic Dosing
- Adult: n/a
- Pediatric: n/a
Contraindications
- Allergy to class/drug
- Cutaneous viral infection of the external auditory canal (e.g. patients with herpes simplex, vaccinia, and varicella infections)
Adverse Reactions
Serious
- Ototoxicity
- Neomycin sensitization with itching, reddening, edema, and failure to heal
- Systemic absorption of topical corticosteroids--> HPA axis suppression --> adrenal crisis
- Prolonged use of corticosteroids may lead to increase incidence of infection, masking of infection, limited response to vaccines
- Prolonged use of corticosteroids associated with development of Kaposi sarcoma
Common
- Itching
- Redness
- Rash
- Swelling
Mechanism of Action
- Hydrocortisone: Suppresses inflammatory response
- Polymyxin: disrupts bacterial cytoplasmic membrane permeability allowing leakage of intracellular contents--> bactericidal
- Neomycin: Inhibits protein synthesis