WLA VA:COVID19: Difference between revisions
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== | ==Introduction== | ||
* Disease name = COVID-19 | |||
* Virus = SARS-CoV-2 (previously 2019-nCoV | |||
=== Virology === | |||
* Coronaviruses are a common human pathogens (discovered in the1960s to cause the common cold). | |||
** During epidemics, they are the cause of up to one-third of community-acquired upper respiratory tract infections in adults; may cause diarrhea in infants and children as well) | |||
* SARS-CoV-2 is a novel coronavirus (a new strain not previously identified in humans) | |||
** Likely primary source = bats | |||
** A betacoronavirus in the same subgenus as the severe acute respiratory syndrome (SARS) virus | |||
** Receptor-binding gene region is very similar to that of the SARS coronavirus (uses angiotensin-converting enzyme 2 [ACE2] for cell entry) | |||
** Middle East respiratory syndrome (MERS) virus, another betacoronavirus, appears more distantly related | |||
* Viral survival time of SARS-CoV-2: | |||
** Stainless steel: persists for 3 hours (or longer) | |||
** Underscores the importance of environmental cleaning / disinfection | |||
*** Cleaning gets rid of the proteins that would interfere with a disinfectants effectiveness | |||
** Note: studied in a simulated lab environment. Lab virions not covered in protein and mucus and other things that would mimic real life and that could prolong survival | |||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 01:52, 18 March 2020
Introduction
- Disease name = COVID-19
- Virus = SARS-CoV-2 (previously 2019-nCoV
Virology
- Coronaviruses are a common human pathogens (discovered in the1960s to cause the common cold).
- During epidemics, they are the cause of up to one-third of community-acquired upper respiratory tract infections in adults; may cause diarrhea in infants and children as well)
- SARS-CoV-2 is a novel coronavirus (a new strain not previously identified in humans)
- Likely primary source = bats
- A betacoronavirus in the same subgenus as the severe acute respiratory syndrome (SARS) virus
- Receptor-binding gene region is very similar to that of the SARS coronavirus (uses angiotensin-converting enzyme 2 [ACE2] for cell entry)
- Middle East respiratory syndrome (MERS) virus, another betacoronavirus, appears more distantly related
- Viral survival time of SARS-CoV-2:
- Stainless steel: persists for 3 hours (or longer)
- Underscores the importance of environmental cleaning / disinfection
- Cleaning gets rid of the proteins that would interfere with a disinfectants effectiveness
- Note: studied in a simulated lab environment. Lab virions not covered in protein and mucus and other things that would mimic real life and that could prolong survival