EBQ:ECASS III: Difference between revisions
(ECASS III) |
(ECASS III) |
||
| Line 24: | Line 24: | ||
==Study Design== | ==Study Design== | ||
*Double blinded, multicenter, randomized controlled trial | |||
**multiple centers across Europe | |||
==Population== | ==Population== | ||
===Patient Demographics=== | ===Patient Demographics=== | ||
Revision as of 06:15, 18 October 2014
incomplete Journal Club Article
Hacke W, et al. "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke". The New England Journal of Medicine. 2008. 359(13):1317-1329.
PubMed Full text PDF
PubMed Full text PDF
Clinical Question
Is ateplase safe and effective for ischemic stroke patients when administered 3 to 4.5 hours after the onset of symptoms?
Conclusion
Patients with ischemic stroke who received IV ateplase 3 to 4.5 hours after symptom onset had significant improvement in clinical outcomes. However, ateplase was associated with more frequent symptomatic intracranial hemorrhage.
Major Points
Study Design
- Double blinded, multicenter, randomized controlled trial
- multiple centers across Europe
Population
Patient Demographics
Inclusion Criteria
Exclusion Criteria
Interventions
Outcomes
Primary Outcome
Secondary Outcomes
Subgroup analysis
Criticisms & Further Discussion
Funding
Sources
[[Category:Neuro]