25C-NBOMe: Difference between revisions
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*2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | *2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | ||
*Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | *Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime | ||
*Potent partial agonist of 5-HT2A receptor | *Potent partial agonist of 5-HT2A receptor</ref name="pharm">Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.</ref> | ||
*Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]] | *Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]] | ||
*Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally | *Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally | ||
*Dose of 50-200 micrograms causes hallucinogenic effects | *Dose of 50-200 micrograms causes hallucinogenic effects<ref name="pharm"></ref> | ||
*Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours | *Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours<ref name="pharm"></ref> | ||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 21:54, 18 December 2014
Background
- 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
- Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
- Potent partial agonist of 5-HT2A receptor</ref name="pharm">Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.</ref>
- Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to LSD
- Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally
- Dose of 50-200 micrograms causes hallucinogenic effects[1]
- Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours[1]
Clinical Features
- Metallic chemical taste
- Sense of numbness of tongue and mouth
- Euphoria
- Visual/Auditory hallucinations
- Stimulation +/- tremors, bruxism
- Serotonin Syndrome (AMS, Hyperthermia, rigidity, autonomic instability)[2]
- Confusion
- Agitation
- Vasoconstriction
- Nausea and Vomiting
- Headache
- Palpitations
- Diaphoresis
- Dysuria
- Hypertension
- Generalized Seizure
- Mydriasis
- Acute Renal Failure
- Metabolic Acidosis
Workup
Hallucination workup
- Urine pregnancy
- CBC, Metabolic panel, LFTs, coags, APAP level, ASA level
- Total CK level
- ECG
- UA
- Tox screen, blood alcohol
- Serum osmoles, urine Na (if Hyponatremia present)
- Head CT as indicated
- LP to rule out Meningitis if infectious symptoms and based on history and physical
Treatment
- ABCs
- IV, O2, monitor
- Agitation
- Benzodiazepines
- Haldol for acute agitation
- Seizure
- Benzodiazepines
- manage airway as indicated
- Hyperthermia:
- ice packs, cold IVF
Disposition
- Admit pt's with complications of ingestion