Phenylephrine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Dosing=== | |||
*Start 100-200mcg/min then taper down | |||
**40-60mcg/min works for most | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
*Baroreceptor-mediated reflex bradycardia | |||
*If extravasates use phentolamine | |||
===Serious=== | ===Serious=== | ||
| Line 31: | Line 37: | ||
*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | |||
*α1 | |||
===Relative Effects=== | |||
*↑SVR | |||
*↓HR (reflex bradycardia) | |||
==Notes== | |||
*Use with caution in pts with spinal cord injury-related bradycardia | |||
*Useful for treatment of vasodilatory shock when norepinephrine or dopamine have precipitated tachyarrhythmias | |||
*In pts with ↓LV function, unopposed α1 may lead to decreased CO or myocardial ischemia | |||
**However clinical trials do not support these effects when used in clinically appropriate dose range | |||
===Indication=== | |||
*Neurogenic Shock | |||
==See Also== | ==See Also== | ||
Revision as of 14:25, 20 December 2014
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- Start 100-200mcg/min then taper down
- 40-60mcg/min works for most
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Baroreceptor-mediated reflex bradycardia
- If extravasates use phentolamine
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- α1
Relative Effects
- ↑SVR
- ↓HR (reflex bradycardia)
Notes
- Use with caution in pts with spinal cord injury-related bradycardia
- Useful for treatment of vasodilatory shock when norepinephrine or dopamine have precipitated tachyarrhythmias
- In pts with ↓LV function, unopposed α1 may lead to decreased CO or myocardial ischemia
- However clinical trials do not support these effects when used in clinically appropriate dose range
Indication
- Neurogenic Shock