Hydrogen sulfide toxicity: Difference between revisions

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HYDROGEN SULFIDE
==Background==
 
#Colorless, flammable gas w/ rotten egg odor
n pathophys identicle to cn except bond of h2s to cytochrome more rapidly reversible than cn. Therefore, just need to remove pt from source and use standard resus measures to reverse h2s toxicity.
#Encountered in oil/gas industries, natural product of decomposition (e.g. septic tank)
 
#Mechanism of toxicity is similar to CN (disruption of aerobic metabolism)
 
HYDROGEN SULFIDE (septic tank)
 
remove pt from source and use standard resus measures


==Clinical Features==
#One of the few chemical asphyxiants that also possesses irritative properities
##Respiratory, ocular irritation
#High conc exposure may result in LOC, sz, and death after only a few breaths
##Delayed pulm edema and corneal destruction should be anticipated w/ massive exposures


==Treatment==
#Decontamination of skin/eyes
#O2 100% NRB
#Consider giving nitrite component of CN kit (do not give thiosulfate portion)
##Low level MetHb may enhance conversion of sulfide to less toxic sulfmethemoglobin


==Source==
Tintinalli


[[Category:Tox]]
[[Category:Tox]]

Revision as of 06:09, 22 September 2011

Background

  1. Colorless, flammable gas w/ rotten egg odor
  2. Encountered in oil/gas industries, natural product of decomposition (e.g. septic tank)
  3. Mechanism of toxicity is similar to CN (disruption of aerobic metabolism)

Clinical Features

  1. One of the few chemical asphyxiants that also possesses irritative properities
    1. Respiratory, ocular irritation
  2. High conc exposure may result in LOC, sz, and death after only a few breaths
    1. Delayed pulm edema and corneal destruction should be anticipated w/ massive exposures

Treatment

  1. Decontamination of skin/eyes
  2. O2 100% NRB
  3. Consider giving nitrite component of CN kit (do not give thiosulfate portion)
    1. Low level MetHb may enhance conversion of sulfide to less toxic sulfmethemoglobin

Source

Tintinalli