Mucormycosis: Difference between revisions
(Created page with "==Definition== Infection of fungal hyphae in immunocompromised hosts -DM -HIV -Neutropenic ==Pathophysiology== Most commonly affects paranasal sinuses (rhinocerebral m...") |
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== | ==Background== | ||
#Infection of fungal hyphae in immunocompromised hosts | |||
##DM | |||
Infection of fungal hyphae in immunocompromised hosts | ##HIV | ||
##Neutropenic | |||
'''Locations''' | |||
#Most commonly affects paranasal sinuses (rhinocerebral mucormycosis) | |||
#Pulmonary | |||
#GI | |||
#CNS | |||
==Diagnosis== | |||
Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic | Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic | ||
Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to: | Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to: | ||
#Vision changes | |||
#Nasopharyngeal and oropharyngeal ulceration or eschars | |||
#Facial edema, pain | |||
#Cranial nerve deficits | |||
#Headache | |||
==Workup== | |||
== | |||
CT scan of sinuses | CT scan of sinuses | ||
==Treatment== | ==Treatment== | ||
#Adjunctive: Amphotericin B (1mgkg/d IV) | |||
#Definitive: Prompt surgical consultation --> debridement | |||
Adjunctive: Amphotericin B (1mgkg/d IV) | |||
Definitive: Prompt surgical consultation --> debridement | |||
==Prognosis== | ==Prognosis== | ||
Mortality 30-90% | Mortality 30-90% | ||
[[Category:ID]] | [[Category:ID]] | ||
Revision as of 04:52, 28 March 2011
Background
- Infection of fungal hyphae in immunocompromised hosts
- DM
- HIV
- Neutropenic
Locations
- Most commonly affects paranasal sinuses (rhinocerebral mucormycosis)
- Pulmonary
- GI
- CNS
Diagnosis
Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic
Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to:
- Vision changes
- Nasopharyngeal and oropharyngeal ulceration or eschars
- Facial edema, pain
- Cranial nerve deficits
- Headache
Workup
CT scan of sinuses
Treatment
- Adjunctive: Amphotericin B (1mgkg/d IV)
- Definitive: Prompt surgical consultation --> debridement
Prognosis
Mortality 30-90%