Template:Endometritis Antibiotics: Difference between revisions
| Line 1: | Line 1: | ||
====<48hrs Post Partum==== | ====<48hrs Post Partum==== | ||
''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ''Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora'' | ||
*(Prefered first line) [[Clindamycin]] 900mg q8hrs PLUS [[Gentamicin]] 5mg/kg IV q24hours (same efficacy and more cost effective vs. 1.5mg/kg) or 1.5mg/kg IV q8hrs OR | *(Prefered first line) [[Clindamycin]] 900mg q8hrs PLUS [[Gentamicin]] 5mg/kg IV q24hours (same efficacy and more cost effective vs. 1.5mg/kg) or 1.5mg/kg IV q8hrs<ref>Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613</ref> OR | ||
*[[Doxycycline]] 100mg IV PO q12hrs daily PLUS | *[[Doxycycline]] 100mg IV PO q12hrs daily PLUS | ||
**[[Ampicillin/Sulbactam]] 3g IV q6hrs | **[[Ampicillin/Sulbactam]] 3g IV q6hrs | ||
Revision as of 21:39, 6 July 2022
<48hrs Post Partum
Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora
- (Prefered first line) Clindamycin 900mg q8hrs PLUS Gentamicin 5mg/kg IV q24hours (same efficacy and more cost effective vs. 1.5mg/kg) or 1.5mg/kg IV q8hrs[1] OR
- Doxycycline 100mg IV PO q12hrs daily PLUS
- Ampicillin/Sulbactam 3g IV q6hrs
- Cefoxitin 2g IV q6hrs daily
>48hrs Post Partum
Use Metronidazole with caution in breastfeeding mothers as Metronidazole and its active hydroxyl metabolite are present in breast milk at concentrations similar to maternal plasma concentrations. Metronidazole and its active metabolite can be detected in the serum of breastfeeding infants (Gray 1961; Heisterberg 1983; Passmore 1988)
- Doxycycline 100mg IV or PO q12hrs + Metronidazole 500mg IV or PO q8hrs daily
- ↑ Mackeen AD, Packard RE, Ota E, Speer L. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861; PMCID: PMC7050613