Thrombocytopenia: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Background== | ==Background== | ||
*Spontaneous bleeding concerning when | *Spontaneous bleeding concerning when platelet count <20K | ||
==Clinical Features== | ==Clinical Features== | ||
| Line 39: | Line 39: | ||
*TTP, DIC, HIT | *TTP, DIC, HIT | ||
===Pediatrics== | ===Pediatrics=== | ||
*1u plt per 5kg body weight raises count by 50k | *1u plt per 5kg body weight raises count by 50k | ||
Revision as of 00:33, 26 April 2015
Background
- Spontaneous bleeding concerning when platelet count <20K
Clinical Features
- Nonpalpable petechiae/purpura
- Mucosal bleeding (gingival, epistaxis)
- Menorrhagia, hemoptysis, hematuria, hematochezia
- Deep tissue bleeding is less common
Causes
- Decreased production
- Marrow infiltration (tumor or infection)
- Viral infections (rubella, HIV)
- Drugs
- Heparin Induced Thrombocytopenia
- sulfa abx, ETOH, ASA, thiazides/furosemide
- Radiation
- Vitamin B12 and/or folate deficiency
- Increased platelet destruction
- Platelet loss
- Excessive hemorrhage
- Hemodialysis, extracorporeal circulation
- Splenic sequestration
- Sickle cell disease, cirrhosis
Treatment
Platelet Transfusion Indications
- <50K & severe bleed or invasive procedure
- <20K & fever, petechia, or infection
- <10K
Transfusion contraindications
- TTP, DIC, HIT
Pediatrics
- 1u plt per 5kg body weight raises count by 50k
See Also
Source
Tintinalli