Clopidogrel: Difference between revisions
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===Common===
===Common===
*bleeding
*pruritus


==Pharmacology==
==Pharmacology==

Revision as of 23:08, 26 June 2015

General

  • Type: Antiplatelet
  • Dosage Forms: 75, 300 PO
  • Common Trade Names: Plavix

Adult Dosing

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • bleeding, severe,
  • hemorrhage
  • TTP
  • agranulocytosis
  • hypersensitivity rxn
  • anaphylactoid rxn
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • erythema multiforme
  • drug rash w/ eosinophilia and systemic sx
  • pneumonia, eosinophilic

Common

  • bleeding
  • pruritus

Pharmacology

  • Half-life: 8h
  • Metabolism: liver, CYP450: 1A2, 2C9, 2C19 (primary), 3A4 substrate
  • Excretion: urine 50%, feces 46%
  • Mechanism of Action: irreversibly binds to P2Y12 adenosine diphosphate receptors, reducing platelet activation and aggregation

See Also

Sources

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