Clopidogrel: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*active bleeding | |||
*caution if trauma | |||
*caution if elective surgery w/in 5 days | |||
*caution if GI disorder | |||
*caution if ocular dz | |||
*caution if poor or intermediate CYP2C19 metabolizer | |||
*caution if renal impairment, mod-severe | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 23:09, 26 June 2015
General
- Type: Antiplatelet
- Dosage Forms: 75, 300 PO
- Common Trade Names: Plavix
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- active bleeding
- caution if trauma
- caution if elective surgery w/in 5 days
- caution if GI disorder
- caution if ocular dz
- caution if poor or intermediate CYP2C19 metabolizer
- caution if renal impairment, mod-severe
Adverse Reactions
Serious
- bleeding, severe,
- hemorrhage
- TTP
- agranulocytosis
- hypersensitivity rxn
- anaphylactoid rxn
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- erythema multiforme
- drug rash w/ eosinophilia and systemic sx
- pneumonia, eosinophilic
Common
- bleeding
- pruritus
Pharmacology
- Half-life: 8h
- Metabolism: liver, CYP450: 1A2, 2C9, 2C19 (primary), 3A4 substrate
- Excretion: urine 50%, feces 46%
- Mechanism of Action: irreversibly binds to P2Y12 adenosine diphosphate receptors, reducing platelet activation and aggregation