Metoclopramide: Difference between revisions
| Line 38: | Line 38: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*extrapyramidal sx | |||
*dystonia, acute | |||
*parkinsonism | |||
*tardive dyskinesia | |||
*neuroleptic malignant syndrome | |||
*seizures | |||
*depression | |||
*suicidality | |||
*hallucinations | |||
*leukopenia | |||
*neutropenia | |||
*agranulocytosis | |||
*methemoglobinemia | |||
*CHF, acute | |||
*AV block | |||
*SVT | |||
*HTN | |||
*angioedema | |||
*hepatotoxicity | |||
*withdrawal sx if abrupt D/C | |||
===Common=== | ===Common=== | ||
Revision as of 20:26, 30 June 2015
General
- Type: anti-emetic
- Dosage Forms: 5, 10; 5/5 mL; IM; IV
- Common Trade Names: Reglan
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- pheochromocytoma
- seizure disorder
- GI bleeding or perforation
- GI obstruction
- caution if depression
- caution if Parkinson dz
- caution if NADH methemoglobin reductase deficiency
- caution if HTN
- caution if CHF
- caution if cirrhosis
- caution if dibetes mellitus
- caution if renal impairment
- caution if neonates
- caution if pediatric pts
- caution if elderly pts, esp. female
Adverse Reactions
Serious
- extrapyramidal sx
- dystonia, acute
- parkinsonism
- tardive dyskinesia
- neuroleptic malignant syndrome
- seizures
- depression
- suicidality
- hallucinations
- leukopenia
- neutropenia
- agranulocytosis
- methemoglobinemia
- CHF, acute
- AV block
- SVT
- HTN
- angioedema
- hepatotoxicity
- withdrawal sx if abrupt D/C
Common
Pharmacology
- Half-life: 5-6h
- Metabolism: liver minimally; CYP450: unknown
- Excretion: urine 85% (20% unchanged), bile/feces 5%
- Mechanism of Action: exact mechanism of action unknown; sensitizes tissues to acetylcholine, stimulating upper GI tract motility; antagonizes central and peripheral dopamine receptors, producing antiemetic effects