Bupropion toxicity: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Agitation | |||
*Dizziness | |||
*Tremor | |||
*[[Nausea/vomiting]] | |||
*Drowsiness | |||
*Tachycardia | |||
*[[Seizure]] | |||
**May develop in isolation from other symptoms | |||
**Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms | |||
==Differential Diagnosis== | |||
==Diagnosis== | |||
==Treatment== | ==Treatment== | ||
*[[GI decontamination]] | |||
**Consider whole-bowel irrigation for sustained-release formulations | |||
*[[Seizure*Treatment|Seizure Treatment]] | |||
**[[Benzos]] are 1st line | |||
**[[Barbituates]] are 2nd line | |||
==Disposition== | ==Disposition== | ||
*Consider discharge if asymptomatic after 8hr for regular-release ingestions | *Consider discharge if asymptomatic after 8hr for regular-release ingestions | ||
== | ==References== | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 12:18, 18 July 2015
Background
- Inhibits reuptake of norepinephrine and dopamine
- Toxicity occurs with ingestion of >450mg/d
Clinical Features
- Agitation
- Dizziness
- Tremor
- Nausea/vomiting
- Drowsiness
- Tachycardia
- Seizure
- May develop in isolation from other symptoms
- Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms
Differential Diagnosis
Diagnosis
Treatment
- GI decontamination
- Consider whole-bowel irrigation for sustained-release formulations
- Seizure Treatment
- Benzos are 1st line
- Barbituates are 2nd line
Disposition
- Consider discharge if asymptomatic after 8hr for regular-release ingestions