Cardiac enzymes: Difference between revisions
| Line 1: | Line 1: | ||
==Markers== | == Markers == | ||
{| | {| cellspacing="1" cellpadding="1" border="1" width="300" class="pbNotSortable" | ||
|- | |- | ||
| myglbn | | '''Name''' | ||
| 1-4h | | '''INTL''' | ||
| 6-7h | | '''ELV PEAK''' | ||
| '''RETRN''' | |||
|- | |||
| myglbn | |||
| 1-4h | |||
| 6-7h | |||
| 18-24h | | 18-24h | ||
|- | |- | ||
| trp I | | trp I | ||
| 3-12 | | 3-12 | ||
| 10-24 | | 10-24 | ||
| 3-10d | | 3-10d | ||
|- | |- | ||
| trp T | | trp T | ||
| 3-12 | | 3-12 | ||
| 10-24 | | 10-24 | ||
| 5-14d | | 5-14d | ||
|- | |- | ||
| ckmb | | ckmb | ||
| 4-12 | | 4-12 | ||
| 12-24 | | 12-24 | ||
| 48-72 | | 48-72 | ||
|- | |- | ||
| ldh | | ldh | ||
| 8-12 | | 8-12 | ||
| 24-48 | | 24-48 | ||
| 10-14d | | 10-14d | ||
|} | |} | ||
<br> | |||
*n I - 2-4 hrs 1st detect | *n I - 2-4 hrs 1st detect | ||
**8-12 hrs w/100% sensitivity | **8-12 hrs w/100% sensitivity | ||
**10-24 peak | **10-24 peak | ||
**5-10 day duration | **5-10 day duration | ||
*Tn T - above plus 5-14 d duration | *Tn T - above plus 5-14 d duration | ||
**CK-MB : 3-4 | **CK-MB : 3-4 | ||
**8-12 (100% sensitive) | **8-12 (100% sensitive) | ||
**10-24 hr peak | **10-24 hr peak</font></font></span> | ||
*MYOGLOBIN : 1-2 hrs detect first | *MYOGLOBIN : 1-2 hrs detect first | ||
**4-8 100% sens | **4-8 100% sens | ||
**4-8 peak | **4-8 peak | ||
**0.5-1.0 duration | **0.5-1.0 duration | ||
**2-4 day duration | **2-4 day duration</font></font></span> | ||
==Creatine Phosphokinase== | ==Creatine Phosphokinase== | ||
Revision as of 20:45, 18 July 2011
Markers
| Name | INTL | ELV PEAK | RETRN |
| myglbn | 1-4h | 6-7h | 18-24h |
| trp I | 3-12 | 10-24 | 3-10d |
| trp T | 3-12 | 10-24 | 5-14d |
| ckmb | 4-12 | 12-24 | 48-72 |
| ldh | 8-12 | 24-48 | 10-14d |
- n I - 2-4 hrs 1st detect
- 8-12 hrs w/100% sensitivity
- 10-24 peak
- 5-10 day duration
- Tn T - above plus 5-14 d duration
- CK-MB : 3-4
- 8-12 (100% sensitive)
- 10-24 hr peak</font></font></span>
- MYOGLOBIN : 1-2 hrs detect first
- 4-8 100% sens
- 4-8 peak
- 0.5-1.0 duration
- 2-4 day duration</font></font></span>
Creatine Phosphokinase
-can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine dz, systemic infections
-if pt small with small muscle mass to begin with, total ck may not be elevated- so better to use ck index- is ratio of ckmb/ total ck. Elevated if > 3- 5%.
-CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami
Troponins
-during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
-troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
-troponin C found in all tissue and is not cardiac marker
-troponin T is qualitative assay.
-troponin I is quantitative assay.