Sympathetic ophthalmia: Difference between revisions
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== | ==Background== | ||
*Uveitis of both eyes, following trauma to one eye | *Uveitis of both eyes, following trauma to one eye | ||
**Due to autoimmune inflammatory response after introduction of immune system to ocular antigens during trauma | **Due to autoimmune inflammatory response after introduction of immune system to ocular antigens during trauma | ||
**Can develop within days to years of initial trauma | **Can develop within days to years of initial trauma | ||
**Affects 0.03 per 100,000 persons per year | **Affects 0.03 per 100,000 persons per year | ||
*Prevention | |||
**Because it is so rare, enucleation often not done immediately, if chance of regaining function | |||
==Clinical Features== | |||
*Symptoms | *Symptoms | ||
**Floaters | **Floaters | ||
**Loss of accommodation | **Loss of accommodation | ||
**Pain, photophobia | **Pain, photophobia | ||
==Differential Diagnosis== | |||
==Diagnosis== | |||
===Work-up=== | |||
===Evaluation=== | |||
==Management== | |||
*Immunosuppressive therapy | |||
*Mild: local corticosteroids and pupillary dilators | |||
*Severe: Systemic steroids, chlorambucil, cyclophosphamide | |||
*Enucleation can reduce symptoms even after the condition has developed | |||
==Disposition== | |||
==See Also== | |||
==External Links== | |||
==References== | ==References== | ||
<references/> | |||
*Rosen's Emergency Medicine | *Rosen's Emergency Medicine | ||
*Sympathetic Ophthalmia: https://en.wikipedia.org/wiki/Sympathetic_ophthalmia. Updated on 17 September 2014. | *Sympathetic Ophthalmia: https://en.wikipedia.org/wiki/Sympathetic_ophthalmia. Updated on 17 September 2014. | ||
Revision as of 03:54, 1 September 2015
Background
- Uveitis of both eyes, following trauma to one eye
- Due to autoimmune inflammatory response after introduction of immune system to ocular antigens during trauma
- Can develop within days to years of initial trauma
- Affects 0.03 per 100,000 persons per year
- Prevention
- Because it is so rare, enucleation often not done immediately, if chance of regaining function
Clinical Features
- Symptoms
- Floaters
- Loss of accommodation
- Pain, photophobia
Differential Diagnosis
Diagnosis
Work-up
Evaluation
Management
- Immunosuppressive therapy
- Mild: local corticosteroids and pupillary dilators
- Severe: Systemic steroids, chlorambucil, cyclophosphamide
- Enucleation can reduce symptoms even after the condition has developed
Disposition
See Also
External Links
References
- Rosen's Emergency Medicine
- Sympathetic Ophthalmia: https://en.wikipedia.org/wiki/Sympathetic_ophthalmia. Updated on 17 September 2014.