Goodpasture syndrome: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Constitutional sx prior to pulmonary/renal complications | |||
*Pulmonary | |||
**Cough, dyspnea, chest pain, hemoptysis, respiratory failure or pulmonary hemorrhage | |||
*Renal | |||
**See [[Glomerulonephritis]] | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 03:50, 24 January 2016
Background
- Goodpasture syndrome (60%): diffuse pulmonary hemorrhage + acute glomerulonephritis.
- Goodpasture disease: glomerulonephritis alone (30%,) pulmonary sx alone (10%,)
- Anti-GBM disease is most precise term for both entities.
- Type II hypersensitivty causing linear IG deposition in glomerular and alveolar BM.
- Triggered by:Sepsis, URI, inhalation injury, smoking, pulmonary edema.
Clinical Features
- Constitutional sx prior to pulmonary/renal complications
- Pulmonary
- Cough, dyspnea, chest pain, hemoptysis, respiratory failure or pulmonary hemorrhage
- Renal
Differential Diagnosis
Diagnosis
Management
- See Hemoptysis