Bupropion toxicity: Difference between revisions
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==Diagnosis== | ==Diagnosis== | ||
== | ==Management== | ||
*[[GI decontamination]] | *[[GI decontamination]] | ||
**Consider whole-bowel irrigation for sustained-release formulations | **Consider whole-bowel irrigation for sustained-release formulations | ||
Revision as of 11:57, 9 July 2016
Background
- Inhibits reuptake of norepinephrine and dopamine
- Toxicity occurs with ingestion of >450mg/d
Clinical Features
- Agitation
- Dizziness
- Tremor
- Nausea/vomiting
- Drowsiness
- Tachycardia
- Seizure
- May develop in isolation from other symptoms
- Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms
Differential Diagnosis
Diagnosis
Management
- GI decontamination
- Consider whole-bowel irrigation for sustained-release formulations
- Seizure Treatment
- Benzos are 1st line
- Barbituates are 2nd line
Disposition
- Consider discharge if asymptomatic after 8hr for regular-release ingestions