Inhaled nitric oxide: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: | *Type: Vasodilator | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: | *Routes of Administration: | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: | ||
*Metabolism: | *Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb. | ||
*Excretion: | *Excretion: Urinary; 70% of inhaled NO excreted within 48 hrs as nitrate | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP | |||
*Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung | |||
==Indications== | |||
*Pulmonary HTN of newborn | |||
*Pulmonary HTN of adults | |||
==Comments== | ==Comments== | ||
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==References== | ==References== | ||
*Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential. Circulation. | |||
2004; 109: 3106-3111 | |||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Revision as of 23:52, 26 April 2016
Administration
- Type: Vasodilator
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.
- Excretion: Urinary; 70% of inhaled NO excreted within 48 hrs as nitrate
Mechanism of Action
- Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP
- Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung
Indications
- Pulmonary HTN of newborn
- Pulmonary HTN of adults
Comments
See Also
References
- Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential. Circulation.
2004; 109: 3106-3111