Carbamazepine toxicity: Difference between revisions
(Created page with "==Background== *Has anticholinergic in addition to antiepileptic effects *Therapeutic concentration: 4-12 ==Clinical Features== *May be delayed and follow crescendo-decrescendo ...") |
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*Therapeutic concentration: 4-12 | *Therapeutic concentration: 4-12 | ||
==Clinical Features== | == Clinical Features == | ||
*May be delayed and follow crescendo-decrescendo course (due to delayed GI motility) | |||
*CNS | *May be delayed and follow crescendo-decrescendo course (due to delayed GI motility) | ||
**Ataxia | *CNS | ||
**Nystagmus | **Ataxia | ||
**Coma | **Nystagmus | ||
*Anticholinergic toxidrome | **Coma | ||
*CV | *Anticholinergic toxidrome | ||
**Dysrhythmias are rare but may occur | *CV | ||
**Widened QRS | **Dysrhythmias are rare but may occur | ||
**Widened QRS | |||
**QT prolongation | |||
==Diagnosis== | ==Diagnosis== | ||
Revision as of 19:38, 5 November 2012
Background
- Has anticholinergic in addition to antiepileptic effects
- Therapeutic concentration: 4-12
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic toxidrome
- CV
- Dysrhythmias are rare but may occur
- Widened QRS
- QT prolongation
Diagnosis
- Levels do not accurately correlate w/ clinical severity
Treatrment
- GI detox
- Activated charcoal (if presents w/in 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider d/c for pt with decreasing levels (measured few hrs apart) and is asymptomatic
Source
- Tintinalli