Amphetamines: Difference between revisions
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==Background== | ==Background== | ||
- central action- increase release & decrease reuptak of dopamine & seratonin. Leads to euphoria & strength | - central action- increase release & decrease reuptak of dopamine & seratonin. Leads to euphoria & strength | ||
- perif action- facilitate synaptic | - perif action- facilitate synaptic xmission @ spinal cord by unknown mech | ||
xmission @ spinal cord by unknown mech | |||
- also cause release of norepi- leads to alpha & beta stim | - also cause release of norepi- leads to alpha & beta stim | ||
==Diagnosis== | ==Diagnosis== | ||
===Alpha=== | |||
Alpha | |||
- pupils dilate | - pupils dilate | ||
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- constrict blood vessels | - constrict blood vessels | ||
===Beta=== | |||
Beta | |||
- inc HR and contractility | - inc HR and contractility | ||
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- dilate muscle beds | - dilate muscle beds | ||
===Mixed=== | |||
Mixed | |||
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion | - delusions, paranoia, aggression, poor judgement, hallucinate, confusion | ||
==Treatment== | ==Treatment== | ||
Benzos | Benzos | ||
==Theraputic Uses== | ==Theraputic Uses== | ||
# appetite suppression | |||
# inc alertness | |||
# narcolepsy | |||
# adhd | |||
# inc mood | |||
# avoid boredom on repetitive task jobs | |||
==Types== | ==Types== | ||
===General=== | |||
- Time- oral- 30min, inhaled instant | - Time- oral- 30min, inhaled instant | ||
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- desipramine and amantadine can give false positive for urine amphet test | - desipramine and amantadine can give false positive for urine amphet test | ||
- hallucinogenic amphet deriv may not show up on tox screen | - hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within | ||
AKA Entactogens- enabling user to touch within | |||
===Meth Amphet=== | |||
- more combative- delusions of parasites- formication\ self mutilate | - more combative- delusions of parasites- formication\ self mutilate | ||
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- AKA ice crystal speed go crank | - AKA ice crystal speed go crank | ||
===MDMA Ecstacy=== | |||
MDMA | |||
- changes 5HT neuroxmitter | - changes 5HT neuroxmitter | ||
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- tolerance developes to positve and neg effects with inc use | - tolerance developes to positve and neg effects with inc use | ||
==Source== | ==Source== | ||
MISTRY 6/06 | MISTRY 6/06 | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 20:20, 11 June 2011
Background
- central action- increase release & decrease reuptak of dopamine & seratonin. Leads to euphoria & strength
- perif action- facilitate synaptic xmission @ spinal cord by unknown mech
- also cause release of norepi- leads to alpha & beta stim
Diagnosis
Alpha
- pupils dilate
- sweat
- decrease gi peristalsis
- constrict blood vessels
Beta
- inc HR and contractility
- dilate bronchi
- dilate muscle beds
Mixed
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
Treatment
Benzos
Theraputic Uses
- appetite suppression
- inc alertness
- narcolepsy
- adhd
- inc mood
- avoid boredom on repetitive task jobs
Types
General
- Time- oral- 30min, inhaled instant
- hepatic and renal excretion- lasts 6- 24 hrs
- if tolerance developes- physical exam may yield normal findings
- desipramine and amantadine can give false positive for urine amphet test
- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within
Meth Amphet
- more combative- delusions of parasites- formication\ self mutilate
- more dysphoric
- AKA ice crystal speed go crank
MDMA Ecstacy
- changes 5HT neuroxmitter
- inc dopamine
- lasts 3 - 5hrs
- usual dose for psychgTx- 50 - 200mg
- cardiac effects
- euphoria- interpersonal clgseness- introspection
- enhanced socialibility (rave)
- deep empathy
- severe withdrawal with anxiety and depression
- tolerance developes to positve and neg effects with inc use
Source
MISTRY 6/06