Cimetidine: Difference between revisions

Revision as of 20:50, 22 January 2017

General

Type: H2 blocker
Dosage Forms: 200, 300, 400, 800mg
Common Trade Names: Tagamet HB 200

Adult Dosing

Duodenal Ulcer, Active

800mg PO QHS x 4-8 weeks

Duodenal Ulcer, Maintenance

400mg PO QHS

Gastric Ulcer, active benign

800mg PO QHS x 6 weeks

H. Pylori Infection

400mg PO BID x 10-28 days

Pediatric Dosing

GERD/PUD

Neonates: 5- 10mg/kg/day PO divided q8-12h
Infants: 10-20mg/kg/day PO divided q8-12h
Children: 20-40mg/kg/day PO divided q6H

Special Populations

Pregnancy Rating: B (animal studies show no risk for adverse fetal effects, human fetal harm possible but unlikely)
Lactation: Probably Safe
Renal Dosing
- Adult: CrCL 10-50: decrease dose 50%, CrCl <10, decrease dose 75%
- Pediatric: CrCl 20-40, decrease dose 25% or give q8h, CrCL <20: decrease dose 50%
Hepatic Dosing
- Adult: Not Defined
- Pediatric not defined

Contraindications

Allergy to class/drug
caution if renal impairment
caution if hepatic impairment
caution in elderly patients
caution if chronic pulmonary disease
caution if DM
caution if immunocompromised

Adverse Reactions

Serious

Anticholinergic toxicity
neutropenia
thrombocytopenia
agranulocytosis
aplastic anemia
pneumonia
depression
psychosis
hallucinations
pancreatitis
interstital nephritis
bradycardia
tachycardia
AV block
skin reaction

Common

headche
diarrhea
dizziness
gynecomastia
nausea
vomiting
confusion
agitation
drowsiness
rash
ALT,AST elevation

Pharmacology

Half-life: 2H
Metabolism: Liver; CYP450, 1A2, 2C19, 2D6 Inhibitor
Excretion: urine
Mechanism of Action: Histamine H2 Receptor blocker

References

Authors:

@@ Line 5: / Line 5: @@
 ==Adult Dosing==
+===Duodenal Ulcer, Active===
+*800mg PO QHS x 4-8 weeks
-Duodenal Ulcer, Active: 800mg PO QHS x 4-8 weeks
+===Duodenal Ulcer, Maintenance===
+*400mg PO QHS
-Duodenal Ulcer, Maintenance: 400mg PO QHS
+===Gastric Ulcer, active benign===
+*800mg PO QHS x 6 weeks
-Gastric Ulcer, active benign: 800mg PO QHS x 6 weeks
+===H. Pylori Infection===
+*400mg PO BID x 10-28 days
-H. Pylori Infection: 400mg PO BID x 10-28 days
 ==Pediatric Dosing==
+===GERD/PUD===
+*Neonates: 5- 10mg/kg/day PO divided q8-12h
-GERD/PUD:
+*Infants: 10-20mg/kg/day PO divided q8-12h
-    *Neonates: 5- 10mg/kg/day PO divided q8-12h
+*Children: 20-40mg/kg/day PO divided q6H
-    *Infants: 10-20mg/kg/day PO divided q8-12h
-    *Children: 20-40mg/kg/day PO divided q6H
 ==Special Populations==
@@ Line 34: / Line 35: @@
 ==Contraindications==
 *Allergy to class/drug
-- caution if renal impairment
+*caution if renal impairment
-- caution if hepatic impairment
+*caution if hepatic impairment
-- caution in elderly patients
+*caution in elderly patients
-- caution if chronic pulmonary disease
+*caution if chronic pulmonary disease
-- caution if DM
+*caution if [[DM]]
-- caution if immunocompromised
+*caution if immunocompromised
 ==Adverse Reactions==
 ===Serious===
-- neutropenia
+*[[Anticholinergic toxicity]]
-- thrombocytopenia
+*[[neutropenia]]
-- agranulocytosis
+*[[thrombocytopenia]]
-- aplastic anemia
+*agranulocytosis
-- pneumonia
+*aplastic anemia
--depression
+*[[pneumonia]]
--psychosis
+*[[depression]]
--hallucinations
+*[[psychosis]]
--pancreatitis
+*[[hallucinations]]
--interstital nephritis
+*[[pancreatitis]]
--bradycardia
+*interstital nephritis
--tachycardia
+*[[bradycardia]]
--AV block
+*[[tachycardia]]
-- skin reaction
+*[[AV block]]
+* skin reaction
 ===Common===
--headche
+*[[headche]]
--diarrhea
+*[[diarrhea]]
--dizziness
+*[[dizziness]]
--gynecomastia
+*gynecomastia
--nausea
+*[[nausea]]
--vomiting
+*[[vomiting]]
--confusion
+*confusion
--agitation
+*agitation
--drowsiness
+*drowsiness
--rash
+*[[rash]]
--ALT,AST elevation
+*ALT,AST elevation
 ==Pharmacology==
@@ Line 78: / Line 80: @@
 ==See Also==
+*[[Anticholinergic toxicity]]
 ==References==